Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 774719..775335 Replicon chromosome
Accession NZ_LT991954
Organism Enterobacter hormaechei subsp. steigerwaltii isolate C309

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DBR08_RS03850 Protein ID WP_017382676.1
Coordinates 774719..775090 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag DBR08_RS03855 Protein ID WP_015569912.1
Coordinates 775093..775335 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBR08_RS03835 772219..773121 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
DBR08_RS03840 773118..773753 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
DBR08_RS03845 773750..774679 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
DBR08_RS03850 774719..775090 - 372 WP_017382676.1 type II toxin-antitoxin system VapC family toxin Toxin
DBR08_RS03855 775093..775335 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
DBR08_RS03860 775534..776454 + 921 WP_017382675.1 alpha/beta hydrolase -
DBR08_RS03865 776463..777404 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
DBR08_RS03870 777449..777886 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
DBR08_RS03875 777883..778764 - 882 WP_003861949.1 virulence factor BrkB family protein -
DBR08_RS03880 778758..779357 - 600 WP_003861947.1 glucose-1-phosphatase -
DBR08_RS03885 779476..780276 - 801 WP_017382673.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13737.88 Da        Isoelectric Point: 6.4882

>T293973 WP_017382676.1 NZ_LT991954:c775090-774719 [Enterobacter hormaechei subsp. steigerwaltii]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT293973 WP_015569912.1 NZ_LT991954:c775335-775093 [Enterobacter hormaechei subsp. steigerwaltii]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References