Detailed information of TA system TA293972

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 646085..646692
• Replicon: chromosome
• Accession: NZ_LT991954
• Organism: Enterobacter hormaechei subsp. steigerwaltii isolate C309

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DBR08_RS03245
• Protein ID: WP_017382585.1
• Coordinates: 646507..646692 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DBR08_RS03240
• Protein ID: WP_017382586.1
• Coordinates: 646085..646492 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBR08_RS03210	641931..642584	+	654	WP_017382590.1	3-keto-L-gulonate-6-phosphate decarboxylase UlaD	-
DBR08_RS03215	642587..643447	+	861	WP_017382589.1	L-ribulose-5-phosphate 3-epimerase	-
DBR08_RS03220	643441..644136	+	696	WP_017382588.1	L-ribulose-5-phosphate 4-epimerase	-
DBR08_RS03225	644137..644424	-	288	Protein_604	helix-turn-helix domain-containing protein	-
DBR08_RS03230	644431..644799	+	369	Protein_605	glycoside hydrolase family 127 protein	-
DBR08_RS03235	645006..646081	+	1076	Protein_606	type I restriction enzyme HsdR N-terminal domain-containing protein	-
DBR08_RS03240	646085..646492	-	408	WP_017382586.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DBR08_RS03245	646507..646692	-	186	WP_017382585.1	type II toxin-antitoxin system HicA family toxin	Toxin
DBR08_RS03250	646942..648480	-	1539	WP_006808612.1	aldehyde dehydrogenase AldB	-
DBR08_RS03255	648647..649531	+	885	WP_017382584.1	ROK family protein	-
DBR08_RS03260	649535..651373	-	1839	WP_017382583.1	selenocysteine-specific translation elongation factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6794.98 Da
• Isoelectric Point: 11.4624

>T293972 WP_017382585.1 NZ_LT991954:c646692-646507 [Enterobacter hormaechei subsp. steigerwaltii]
VKSADIIAVLVSHGWKCVRTTGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15171.94 Da
• Isoelectric Point: 4.3197

>AT293972 WP_017382586.1 NZ_LT991954:c646492-646085 [Enterobacter hormaechei subsp. steigerwaltii]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEAFPLPGNVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp