Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 45558..46194 Replicon plasmid PP3
Accession NZ_LT985194
Organism Pseudomonas syringae strain CFBP 2116

Toxin (Protein)


Gene name hicA Uniprot ID A0A2S4IFM0
Locus tag DTQ61_RS29760 Protein ID WP_044310977.1
Coordinates 45558..45740 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2S4IFN3
Locus tag DTQ61_RS29765 Protein ID WP_060404204.1
Coordinates 45772..46194 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DTQ61_RS29735 42011..43240 - 1230 WP_104721077.1 IS91 family transposase -
DTQ61_RS29740 43221..43502 - 282 WP_060407302.1 hypothetical protein -
DTQ61_RS29750 43776..45002 - 1227 WP_104721076.1 IS91 family transposase -
DTQ61_RS29760 45558..45740 + 183 WP_044310977.1 type II toxin-antitoxin system HicA family toxin Toxin
DTQ61_RS29765 45772..46194 + 423 WP_060404204.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DTQ61_RS29770 46360..46671 + 312 Protein_52 hypothetical protein -
DTQ61_RS29775 46703..49729 - 3027 WP_060404205.1 Tn3-like element ISPsy30 family transposase -
DTQ61_RS29780 49719..50315 - 597 WP_057425230.1 recombinase family protein -
DTQ61_RS31005 50632..51162 - 531 WP_005752338.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..83816 83816
- inside IScluster/Tn - - 37991..58188 20197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6836.96 Da        Isoelectric Point: 10.5498

>T293969 WP_044310977.1 NZ_LT985194:45558-45740 [Pseudomonas syringae]
MKCSEFRRWLQAQGAEFKAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKTIIKQLGLKD

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15616.00 Da        Isoelectric Point: 5.1895

>AT293969 WP_060404204.1 NZ_LT985194:45772-46194 [Pseudomonas syringae]
MYQYPLTQHQEQTGVWLSCPNIPEMNASGETLTEALDEALNGMESALSLYVDQRRKIPQASLPVGDELVMHLPALTVAKI
MLWNSMLDNGVSRAELARRLGCTRQVVDRLVDFLHTSKIEQVERALGLLGRRITLSLEAA

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4IFM0

Antitoxin

Source ID Structure
AlphaFold DB A0A2S4IFN3

References