Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1775867..1776432 Replicon chromosome
Accession NZ_LT985188
Organism Micropruina glycogenica isolate

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MPLG2_RS08250 Protein ID WP_173909653.1
Coordinates 1776082..1776432 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MPLG2_RS08245 Protein ID WP_173909652.1
Coordinates 1775867..1776085 (+) Length 73 a.a.

Genomic Context

MPLG2_RS08210MPLG2_RS08225MPLG2_RS08230MPLG2_RS08245MPLG2_RS08250MPLG2_RS08275MPLG2_RS08215MPLG2_RS08235MPLG2_RS08240MPLG2_RS08260MPLG2_RS08265MPLG2_RS08270
Location: 1771186..1771794 (609 bp)
Type: Others
Protein ID: WP_105185707.1
Location: 1773564..1773752 (189 bp)
Type: Others
Protein ID: WP_105185708.1
Location: 1773736..1774623 (888 bp)
Type: Others
Protein ID: WP_105185709.1
Location: 1775867..1776085 (219 bp)
Type: Antitoxin
Protein ID: WP_173909652.1
Location: 1776082..1776432 (351 bp)
Type: Toxin
Protein ID: WP_173909653.1
Location: 1780277..1780687 (411 bp)
Type: Others
Protein ID: WP_197710121.1
Location: 1771822..1773102 (1281 bp)
Type: Others
Protein ID: WP_197709915.1
Location: 1774655..1774852 (198 bp)
Type: Others
Protein ID: WP_105185710.1
Location: 1774843..1775013 (171 bp)
Type: Others
Protein ID: WP_158680984.1
Location: 1777024..1777362 (339 bp)
Type: Others
Protein ID: WP_105185714.1
Location: 1777487..1778434 (948 bp)
Type: Others
Protein ID: WP_105185715.1
Location: 1778436..1778981 (546 bp)
Type: Others
Protein ID: WP_105185429.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MPLG2_RS082101771186..1771794+609WP_105185707.1MarR family winged helix-turn-helix transcriptional regulator-
MPLG2_RS082151771822..1773102-1281WP_197709915.1DDE-type integrase/transposase/recombinase-
MPLG2_RS082251773564..1773752+189WP_105185708.1hypothetical protein-
MPLG2_RS082301773736..1774623+888WP_105185709.1site-specific integrase-
MPLG2_RS082351774655..1774852-198WP_105185710.1helix-turn-helix domain-containing protein-
MPLG2_RS082401774843..1775013-171WP_158680984.1hypothetical protein-
MPLG2_RS082451775867..1776085+219WP_173909652.1ribbon-helix-helix domain-containing proteinAntitoxin
MPLG2_RS082501776082..1776432+351WP_173909653.1type II toxin-antitoxin system PemK/MazF family toxinToxin
MPLG2_RS082601777024..1777362-339WP_105185714.1hypothetical protein-
MPLG2_RS082651777487..1778434-948WP_105185715.1hypothetical protein-
MPLG2_RS082701778436..1778981-546WP_105185429.1sigma-70 family RNA polymerase sigma factor-
MPLG2_RS082751780277..1780687+411WP_197710121.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1774843..17841429299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-37)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12653.69 Da        Isoelectric Point: 11.1582

>T293961 WP_173909653.1 NZ_LT985188:1776082-1776432 [Micropruina glycogenica]
MMLRGEIRLTDLDPARAAEADTRRPAIIVSNDRANATAARLGRGVVTVVPITSNISRVFPFQVLLPADDVGIRVDSKAQA
EQVRSVSIERIGPVIGRLPTHLISKLDDALRLHLQL

Download         Length: 351 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7608.37 Da        Isoelectric Point: 3.9944

>AT293961 WP_173909652.1 NZ_LT985188:1775867-1776085 [Micropruina glycogenica]
VKLSVSLSPSEVETLDKYARAAGLKSRSAAIQQAIKLLGDPELEDAYAAAWQEWEDSGESEAWAGTVADGLG

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References