Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1775867..1776432 Replicon chromosome
Accession NZ_LT985188
Organism Micropruina glycogenica isolate

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MPLG2_RS08250 Protein ID WP_173909653.1
Coordinates 1776082..1776432 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MPLG2_RS08245 Protein ID WP_173909652.1
Coordinates 1775867..1776085 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPLG2_RS08210 1771186..1771794 + 609 WP_105185707.1 MarR family winged helix-turn-helix transcriptional regulator -
MPLG2_RS08215 1771822..1773102 - 1281 WP_197709915.1 DDE-type integrase/transposase/recombinase -
MPLG2_RS08225 1773564..1773752 + 189 WP_105185708.1 hypothetical protein -
MPLG2_RS08230 1773736..1774623 + 888 WP_105185709.1 site-specific integrase -
MPLG2_RS08235 1774655..1774852 - 198 WP_105185710.1 helix-turn-helix domain-containing protein -
MPLG2_RS08240 1774843..1775013 - 171 WP_158680984.1 hypothetical protein -
MPLG2_RS08245 1775867..1776085 + 219 WP_173909652.1 ribbon-helix-helix domain-containing protein Antitoxin
MPLG2_RS08250 1776082..1776432 + 351 WP_173909653.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MPLG2_RS08260 1777024..1777362 - 339 WP_105185714.1 hypothetical protein -
MPLG2_RS08265 1777487..1778434 - 948 WP_105185715.1 hypothetical protein -
MPLG2_RS08270 1778436..1778981 - 546 WP_105185429.1 sigma-70 family RNA polymerase sigma factor -
MPLG2_RS08275 1780277..1780687 + 411 WP_197710121.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1774843..1784142 9299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-37)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12653.69 Da        Isoelectric Point: 11.1582

>T293961 WP_173909653.1 NZ_LT985188:1776082-1776432 [Micropruina glycogenica]
MMLRGEIRLTDLDPARAAEADTRRPAIIVSNDRANATAARLGRGVVTVVPITSNISRVFPFQVLLPADDVGIRVDSKAQA
EQVRSVSIERIGPVIGRLPTHLISKLDDALRLHLQL

Download         Length: 351 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7608.37 Da        Isoelectric Point: 3.9944

>AT293961 WP_173909652.1 NZ_LT985188:1775867-1776085 [Micropruina glycogenica]
VKLSVSLSPSEVETLDKYARAAGLKSRSAAIQQAIKLLGDPELEDAYAAAWQEWEDSGESEAWAGTVADGLG

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References