293953

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 7014326..7015019 Replicon chromosome
Accession NZ_LT969520
Organism Pseudomonas aeruginosa isolate RW109

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag RW109_RS37090 Protein ID WP_003151133.1
Coordinates 7014642..7015019 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag RW109_RS37085 Protein ID WP_001172026.1
Coordinates 7014326..7014661 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RW109_RS37050 7009951..7010964 + 1014 Protein_6560 transposase -
RW109_RS37055 7011253..7012047 + 795 WP_008328897.1 hydratase -
RW109_RS37060 7012355..7012618 - 264 Protein_6562 transposase -
RW109_RS37065 7012763..7013218 + 456 Protein_6563 DUF4158 domain-containing protein -
RW109_RS37070 7013258..7013629 - 372 WP_023103794.1 hypothetical protein -
RW109_RS37075 7013626..7013952 - 327 WP_000091614.1 hypothetical protein -
RW109_RS37080 7013976..7014311 - 336 WP_000741275.1 hypothetical protein -
RW109_RS37085 7014326..7014661 - 336 WP_001172026.1 helix-turn-helix domain-containing protein Antitoxin
RW109_RS37090 7014642..7015019 - 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RW109_RS37095 7015211..7015813 + 603 WP_010465829.1 recombinase family protein -
RW109_RS37100 7015797..7018826 + 3030 WP_057384098.1 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 6991120..7015813 24693
- inside IScluster/Tn - - 6991120..7018826 27706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T293953 WP_003151133.1 NZ_LT969520:c7015019-7014642 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT293953 WP_001172026.1 NZ_LT969520:c7014661-7014326 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References