293952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 6973607..6974300 Replicon chromosome
Accession NZ_LT969520
Organism Pseudomonas aeruginosa isolate RW109

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag RW109_RS36840 Protein ID WP_003151133.1
Coordinates 6973607..6973984 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag RW109_RS36845 Protein ID WP_001172026.1
Coordinates 6973965..6974300 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RW109_RS36830 6969800..6972829 - 3030 WP_057384098.1 Tn3 family transposase -
RW109_RS36835 6972813..6973415 - 603 WP_010465829.1 recombinase family protein -
RW109_RS36840 6973607..6973984 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RW109_RS36845 6973965..6974300 + 336 WP_001172026.1 helix-turn-helix domain-containing protein Antitoxin
RW109_RS36850 6974315..6974650 + 336 WP_000741275.1 hypothetical protein -
RW109_RS36855 6974674..6975000 + 327 WP_000091614.1 hypothetical protein -
RW109_RS36860 6974997..6975368 + 372 WP_023103794.1 hypothetical protein -
RW109_RS36865 6975408..6976022 + 615 Protein_6523 FAD-dependent oxidoreductase -
RW109_RS36870 6976040..6976405 + 366 WP_000995360.1 mercury resistance co-regulator MerD -
RW109_RS36875 6976402..6976638 + 237 WP_003132004.1 broad-spectrum mercury transporter MerE -
RW109_RS36880 6976635..6977624 + 990 WP_003132006.1 DUF3330 domain-containing protein -
RW109_RS36885 6978240..6979166 - 927 WP_047219935.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T293952 WP_003151133.1 NZ_LT969520:6973607-6973984 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT293952 WP_001172026.1 NZ_LT969520:6973965-6974300 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References