Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5656901..5657487 Replicon chromosome
Accession NZ_LT969520
Organism Pseudomonas aeruginosa isolate RW109

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag RW109_RS30540 Protein ID WP_003120987.1
Coordinates 5657188..5657487 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag RW109_RS30535 Protein ID WP_003448662.1
Coordinates 5656901..5657191 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RW109_RS30515 5652052..5652261 + 210 WP_003105733.1 cold-shock protein -
RW109_RS30520 5652483..5654372 + 1890 WP_016851610.1 hypothetical protein -
RW109_RS30525 5654369..5656345 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
RW109_RS30530 5656486..5656830 + 345 WP_016851612.1 hypothetical protein -
RW109_RS30535 5656901..5657191 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
RW109_RS30540 5657188..5657487 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RW109_RS30545 5657689..5658813 + 1125 WP_012076859.1 TcpQ domain-containing protein -
RW109_RS30550 5658813..5660522 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
RW109_RS30555 5660526..5661851 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
RW109_RS30560 5661841..5662374 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5632149..5657487 25338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T293949 WP_003120987.1 NZ_LT969520:c5657487-5657188 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT293949 WP_003448662.1 NZ_LT969520:c5657191-5656901 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References