Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4827435..4828693 Replicon chromosome
Accession NZ_LT969520
Organism Pseudomonas aeruginosa isolate RW109

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag RW109_RS26535 Protein ID WP_003086331.1
Coordinates 4827435..4828190 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag RW109_RS26540 Protein ID WP_003086329.1
Coordinates 4828325..4828693 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RW109_RS26525 4822606..4825149 + 2544 WP_033955245.1 acyl-homoserine-lactone acylase QuiP -
RW109_RS26530 4825305..4826666 - 1362 WP_003120632.1 DNA recombination protein RmuC -
RW109_RS26535 4827435..4828190 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
RW109_RS26540 4828325..4828693 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
RW109_RS26545 4828766..4830052 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
RW109_RS26550 4830108..4831697 - 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
RW109_RS26555 4831776..4832252 + 477 WP_004353334.1 elongation factor GreAB -
RW109_RS38635 4832255..4832530 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T293948 WP_003086331.1 NZ_LT969520:c4828190-4827435 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT293948 WP_003086329.1 NZ_LT969520:c4828693-4828325 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References