Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3839951..3841172 Replicon chromosome
Accession NZ_LT969520
Organism Pseudomonas aeruginosa isolate RW109

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag RW109_RS21560 Protein ID WP_003110488.1
Coordinates 3840594..3841172 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RW109_RS21555 Protein ID WP_003088112.1
Coordinates 3839951..3840505 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RW109_RS21530 3835519..3836070 + 552 WP_003450159.1 XRE family transcriptional regulator -
RW109_RS21535 3836067..3836465 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
RW109_RS21540 3836478..3836801 - 324 WP_015648646.1 multidrug efflux SMR transporter -
RW109_RS21545 3837132..3837593 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
RW109_RS21550 3837598..3839793 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
RW109_RS21555 3839951..3840505 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
RW109_RS21560 3840594..3841172 + 579 WP_003110488.1 HD domain-containing protein Toxin
RW109_RS21565 3841281..3842468 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
RW109_RS21570 3842458..3844629 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
RW109_RS21575 3844619..3845896 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T293947 WP_003110488.1 NZ_LT969520:3840594-3841172 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT293947 WP_003088112.1 NZ_LT969520:3839951-3840505 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References