Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rnlAB/RnlA-RnlB
Location 1183542..1184963 Replicon chromosome
Accession NZ_LT969520
Organism Pseudomonas aeruginosa isolate RW109

Toxin (Protein)


Gene name rnlA Uniprot ID -
Locus tag RW109_RS09015 Protein ID WP_025297643.1
Coordinates 1183890..1184963 (-) Length 358 a.a.

Antitoxin (Protein)


Gene name rnlB Uniprot ID -
Locus tag RW109_RS09010 Protein ID WP_158025315.1
Coordinates 1183542..1183835 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RW109_RS08965 1178645..1178857 + 213 WP_023128602.1 hypothetical protein -
RW109_RS08970 1178948..1179403 - 456 WP_025297646.1 helix-turn-helix domain-containing protein -
RW109_RS08975 1179568..1179963 + 396 WP_023128603.1 hypothetical protein -
RW109_RS08980 1180006..1180476 + 471 WP_023128604.1 hypothetical protein -
RW109_RS08985 1180479..1180862 + 384 WP_025297645.1 hypothetical protein -
RW109_RS08990 1180944..1181522 + 579 WP_057384237.1 hypothetical protein -
RW109_RS08995 1181853..1182217 + 365 Protein_1144 DNA binding protein -
RW109_RS09000 1182441..1182635 - 195 WP_023128607.1 OprD family outer membrane porin -
RW109_RS09005 1182634..1183329 + 696 WP_196747054.1 transporter substrate-binding domain-containing protein -
RW109_RS09010 1183542..1183835 - 294 WP_158025315.1 type II toxin-antitoxin system RnlB family antitoxin Antitoxin
RW109_RS09015 1183890..1184963 - 1074 WP_025297643.1 type II toxin-antitoxin system RnlA family toxin Toxin
RW109_RS09020 1185678..1185932 + 255 WP_023128610.1 hypothetical protein -
RW109_RS09030 1186230..1186526 + 297 WP_023128612.1 hypothetical protein -
RW109_RS09035 1186579..1188162 - 1584 WP_025297642.1 hypothetical protein -
RW109_RS09040 1188442..1188870 + 429 WP_025297641.1 S24 family peptidase -
RW109_RS09045 1188857..1188976 + 120 Protein_1153 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1170272..1199486 29214


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterial toxin, RNase RnlA/LsoA, N-terminal

(6-87)

Antitoxin

Antitoxin RnlB/LsoB

(2-96)


Sequences

Toxin        


Download         Length: 358 a.a.        Molecular weight: 40381.89 Da        Isoelectric Point: 6.1830

>T293945 WP_025297643.1 NZ_LT969520:c1184963-1183890 [Pseudomonas aeruginosa]
VTERDYKNINLKRCIIEETTHCFIRDNGLKLRSYGDKPGSSGLRVVFGKAGIEDATLDIFFTNVGASTLTYKVGKNQALG
QQLADALYETIHPDEFVTMNLGIKGVDLDDAEALIKELTESANADIEVASRTSADRKHIWKLKSKKNLDELTVTQHENTH
KLQIQGRPLSCYQQLSYLLTELLEINALECILFKKEENRSEFVCAEVAESVLKERFGDCYANLPQTSRRLLLASLCVRLA
SPALPDYCMLVYPELRTLEGAIKQKLAEKNLSNQEESFGGFFTKTNGQFYLKQQYHADVGDAKLQGHLDNAYTFFNKQRH
GLFHMEEMPSVSRMISNITQAVSLCDEAYDHIKNLYS

Download         Length: 1074 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11039.38 Da        Isoelectric Point: 4.5163

>AT293945 WP_158025315.1 NZ_LT969520:c1183835-1183542 [Pseudomonas aeruginosa]
MTVVTATSYENPLSRLSIIASEMRNTSHSSKEIVLFDLLCSNGEEWNRFVSINYNGTDFEKSTCSIVSKSDIPTDLLETQ
TRFFQIHPQYLLDSVLN

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References