Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 112624..113540 | Replicon | plasmid RW109 plasmid 1 |
| Accession | NZ_LT969519 | ||
| Organism | Pseudomonas aeruginosa isolate RW109 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A212BIN6 |
| Locus tag | RW109_RS00545 | Protein ID | WP_021018402.1 |
| Coordinates | 113016..113540 (+) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A2I0C738 |
| Locus tag | RW109_RS00540 | Protein ID | WP_010792483.1 |
| Coordinates | 112624..113019 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RW109_RS00520 | 108501..109553 | + | 1053 | WP_027590394.1 | extracellular solute-binding protein | - |
| RW109_RS00525 | 109566..110438 | + | 873 | WP_052155488.1 | ABC transporter permease subunit | - |
| RW109_RS00530 | 110425..111165 | + | 741 | Protein_102 | ABC transporter permease subunit | - |
| RW109_RS00535 | 111164..112414 | + | 1251 | Protein_103 | helicase | - |
| RW109_RS00540 | 112624..113019 | + | 396 | WP_010792483.1 | hypothetical protein | Antitoxin |
| RW109_RS00545 | 113016..113540 | + | 525 | WP_021018402.1 | RES family NAD+ phosphorylase | Toxin |
| RW109_RS00550 | 113586..114836 | - | 1251 | WP_010792484.1 | TerD family protein | - |
| RW109_RS00555 | 115033..116088 | - | 1056 | WP_021018403.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| RW109_RS00560 | 116466..116657 | + | 192 | WP_010792486.1 | hypothetical protein | - |
| RW109_RS00570 | 117079..118224 | - | 1146 | WP_021018404.1 | glycerate kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | adeG | 1..555265 | 555265 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 19011.47 Da Isoelectric Point: 4.4540
>T293943 WP_021018402.1 NZ_LT969519:113016-113540 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
Download Length: 525 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14810.93 Da Isoelectric Point: 7.2048
>AT293943 WP_010792483.1 NZ_LT969519:112624-113019 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A212BIN6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I0C738 |