Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 948948..949754 Replicon chromosome
Accession NZ_LT963436
Organism Staphylococcus saprophyticus isolate Staphylococcus saprophyticus 883

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag DG022_RS04705 Protein ID WP_011302805.1
Coordinates 949569..949754 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q49YQ1
Locus tag DG022_RS04700 Protein ID WP_011302804.1
Coordinates 948948..949547 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG022_RS04680 944826..946289 + 1464 WP_047502301.1 ABC transporter substrate-binding protein/permease -
DG022_RS04685 946282..947004 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
DG022_RS04690 947165..948292 + 1128 WP_078073240.1 tRNA epoxyqueuosine(34) reductase QueG -
DG022_RS04695 948297..948767 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DG022_RS04700 948948..949547 + 600 WP_011302804.1 glucosamine-6-phosphate isomerase Antitoxin
DG022_RS04705 949569..949754 + 186 WP_011302805.1 hypothetical protein Toxin
DG022_RS04710 949911..950327 + 417 WP_069826778.1 hypothetical protein -
DG022_RS04715 950705..952090 + 1386 WP_011302807.1 class II fumarate hydratase -
DG022_RS04720 952293..953120 - 828 WP_069822437.1 RluA family pseudouridine synthase -
DG022_RS04725 953305..954420 + 1116 WP_011302809.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T293940 WP_011302805.1 NZ_LT963436:949569-949754 [Staphylococcus saprophyticus]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22279.11 Da        Isoelectric Point: 4.8524

>AT293940 WP_011302804.1 NZ_LT963436:948948-949547 [Staphylococcus saprophyticus]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSAREVILIITGSDKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB Q49YQ1

References