Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 819012..819541 Replicon chromosome
Accession NZ_LT963436
Organism Staphylococcus saprophyticus isolate Staphylococcus saprophyticus 883

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DG022_RS03940 Protein ID WP_002482752.1
Coordinates 819179..819541 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A380HJK7
Locus tag DG022_RS03935 Protein ID WP_037538046.1
Coordinates 819012..819182 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG022_RS03910 814743..815222 + 480 WP_011302698.1 PH domain-containing protein -
DG022_RS03915 815215..816753 + 1539 WP_078073322.1 PH domain-containing protein -
DG022_RS03920 816746..817246 + 501 WP_047503185.1 PH domain-containing protein -
DG022_RS03925 817310..817660 + 351 WP_002482750.1 holo-ACP synthase -
DG022_RS03930 817776..818924 + 1149 WP_047503183.1 alanine racemase -
DG022_RS03935 819012..819182 + 171 WP_037538046.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DG022_RS03940 819179..819541 + 363 WP_002482752.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DG022_RS03945 819878..820879 + 1002 WP_041080774.1 PP2C family protein-serine/threonine phosphatase -
DG022_RS03950 820958..821284 + 327 WP_011302705.1 anti-sigma factor antagonist -
DG022_RS03955 821286..821768 + 483 WP_002482755.1 anti-sigma B factor RsbW -
DG022_RS03960 821743..822513 + 771 WP_002482756.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13498.70 Da        Isoelectric Point: 10.3173

>T293939 WP_002482752.1 NZ_LT963436:819179-819541 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHTIRSHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6304.97 Da        Isoelectric Point: 4.0121

>AT293939 WP_037538046.1 NZ_LT963436:819012-819182 [Staphylococcus saprophyticus]
MASFNQSRIHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A380HJK7

References