293938

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 807341..807855 Replicon chromosome
Accession NZ_LT963436
Organism Staphylococcus saprophyticus isolate Staphylococcus saprophyticus 883

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag DG022_RS03880 Protein ID WP_002482741.1
Coordinates 807649..807855 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag DG022_RS03875 Protein ID WP_002482740.1
Coordinates 807341..807634 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DG022_RS03850 802503..803294 + 792 WP_047503196.1 hydroxyethylthiazole kinase -
DG022_RS03855 803294..803932 + 639 WP_011302689.1 thiamine phosphate synthase -
DG022_RS03860 804020..804889 + 870 WP_011302690.1 membrane protein insertase YidC -
DG022_RS03865 804971..805618 - 648 WP_174165678.1 HD domain-containing protein -
DG022_RS03870 805714..807198 - 1485 WP_078073321.1 cardiolipin synthase -
DG022_RS03875 807341..807634 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
DG022_RS03880 807649..807855 + 207 WP_002482741.1 hypothetical protein Toxin
DG022_RS03885 808069..808209 + 141 WP_002482742.1 hypothetical protein -
DG022_RS03890 808502..809707 - 1206 WP_011302694.1 rod shape-determining protein RodA -
DG022_RS03895 809956..811026 + 1071 WP_011302695.1 D-alanine--D-alanine ligase -
DG022_RS03900 811039..812394 + 1356 WP_047503189.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T293938 WP_002482741.1 NZ_LT963436:807649-807855 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT293938 WP_002482740.1 NZ_LT963436:807341-807634 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References