Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4695..5331 Replicon plasmid PP4
Accession NZ_LT963413
Organism Pseudomonas syringae isolate CFBP3840

Toxin (Protein)


Gene name hicA Uniprot ID A0A2S4IFM0
Locus tag C6H39_RS30505 Protein ID WP_044310977.1
Coordinates 5149..5331 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2S4IFN3
Locus tag C6H39_RS30500 Protein ID WP_060404204.1
Coordinates 4695..5117 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H39_RS30485 574..1170 + 597 WP_057425230.1 recombinase family protein -
C6H39_RS30490 1160..4186 + 3027 WP_060404205.1 Tn3-like element ISPsy30 family transposase -
C6H39_RS30495 4218..4529 - 312 Protein_3 hypothetical protein -
C6H39_RS30500 4695..5117 - 423 WP_060404204.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C6H39_RS30505 5149..5331 - 183 WP_044310977.1 type II toxin-antitoxin system HicA family toxin Toxin
C6H39_RS30510 5624..5905 + 282 WP_060402791.1 hypothetical protein -
C6H39_RS30515 5886..7112 + 1227 WP_104721076.1 IS91 family transposase -
C6H39_RS30525 7386..7667 + 282 WP_060407302.1 hypothetical protein -
C6H39_RS30530 7648..8877 + 1230 WP_104721077.1 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..78348 78348
- inside IScluster/Tn - - 574..12897 12323


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6836.96 Da        Isoelectric Point: 10.5498

>T293936 WP_044310977.1 NZ_LT963413:c5331-5149 [Pseudomonas syringae]
MKCSEFRRWLQAQGAEFKAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKTIIKQLGLKD

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15616.00 Da        Isoelectric Point: 5.1895

>AT293936 WP_060404204.1 NZ_LT963413:c5117-4695 [Pseudomonas syringae]
MYQYPLTQHQEQTGVWLSCPNIPEMNASGETLTEALDEALNGMESALSLYVDQRRKIPQASLPVGDELVMHLPALTVAKI
MLWNSMLDNGVSRAELARRLGCTRQVVDRLVDFLHTSKIEQVERALGLLGRRITLSLEAA

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4IFM0

Antitoxin

Source ID Structure
AlphaFold DB A0A2S4IFN3

References