Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 14259..14833 Replicon plasmid PP3
Accession NZ_LT963412
Organism Pseudomonas syringae isolate CFBP3840

Toxin (Protein)


Gene name vapC Uniprot ID Q48BC5
Locus tag C6H39_RS30115 Protein ID WP_003344395.1
Coordinates 14456..14833 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q48BC4
Locus tag C6H39_RS30110 Protein ID WP_004644067.1
Coordinates 14259..14459 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H39_RS30095 9659..10627 - 969 WP_060402986.1 hypothetical protein -
C6H39_RS30100 11004..13094 - 2091 Protein_14 type IV secretory system conjugative DNA transfer family protein -
C6H39_RS30105 13081..14166 - 1086 WP_060404100.1 thioredoxin fold domain-containing protein -
C6H39_RS30110 14259..14459 + 201 WP_004644067.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C6H39_RS30115 14456..14833 + 378 WP_003344395.1 PIN domain-containing protein Toxin
C6H39_RS30120 14823..16025 - 1203 WP_044424879.1 hypothetical protein -
C6H39_RS30125 16118..16777 - 660 WP_044424882.1 plasmid IncI1-type surface exclusion protein ExcA -
C6H39_RS30130 16764..18908 - 2145 WP_060404099.1 DotA/TraY family protein -
C6H39_RS30135 19039..19617 - 579 WP_004642775.1 conjugal transfer protein TraX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..86369 86369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13633.73 Da        Isoelectric Point: 6.4723

>T293934 WP_003344395.1 NZ_LT963412:14456-14833 [Pseudomonas syringae]
VKGVLVDTSVWVEHFRNNSPELVNLLSQDRVLIHPMVIGELACGTPPDRSNTLTDLGDLRGAQQPTVSEVIAFLNTHKLY
GLGCGLVDMTLLASALLSGTALWTLDKRLERLASRMAVSYQPPTH

Download         Length: 378 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7445.66 Da        Isoelectric Point: 7.0102

>AT293934 WP_004644067.1 NZ_LT963412:14259-14459 [Pseudomonas syringae]
MRTTVTIDDALYQRALEVADPAMDKADLFREAVQTFVRIQAAKRLMALGATLPTMEDIARRHEKAL

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3GPE2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S4IKB9

References