Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5851445..5852025 Replicon chromosome
Accession NZ_LT963409
Organism Pseudomonas syringae isolate CFBP3840

Toxin (Protein)


Gene name PumA Uniprot ID A0A2G4CV40
Locus tag C6H39_RS27890 Protein ID WP_044322659.1
Coordinates 5851445..5851744 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2G4CUT8
Locus tag C6H39_RS27895 Protein ID WP_003407168.1
Coordinates 5851741..5852025 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H39_RS27860 5848202..5848843 - 642 WP_060403107.1 SOS response-associated peptidase -
C6H39_RS27865 5849108..5849359 - 252 WP_003348789.1 ribbon-helix-helix protein, CopG family -
C6H39_RS27870 5849448..5850101 - 654 WP_060403115.1 AAA family ATPase -
C6H39_RS27880 5850497..5850913 - 417 WP_060403106.1 hypothetical protein -
C6H39_RS27890 5851445..5851744 + 300 WP_044322659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6H39_RS27895 5851741..5852025 + 285 WP_003407168.1 putative addiction module antidote protein Antitoxin
C6H39_RS27900 5852100..5852408 - 309 WP_180275929.1 DUF4113 domain-containing protein -
C6H39_RS27905 5852781..5853799 + 1019 Protein_5211 tyrosine protein phosphatase -
C6H39_RS27910 5854363..5854584 - 222 WP_004666801.1 hypothetical protein -
C6H39_RS27915 5854735..5855820 + 1086 WP_002556026.1 DUF3616 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5849448..5866785 17337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(10-92)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11170.80 Da        Isoelectric Point: 9.9231

>T293930 WP_044322659.1 NZ_LT963409:5851445-5851744 [Pseudomonas syringae]
MTTIKQTSTYMAWERRLKDQKAKAAIAARIFRVANGLMGDVSPVGQGVSELRIHVGPGYRVYFQQRGDELILLLCGGDKS
SQSRDIETAKKLADQWWQE

Download         Length: 300 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10277.83 Da        Isoelectric Point: 5.0916

>AT293930 WP_003407168.1 NZ_LT963409:5851741-5852025 [Pseudomonas syringae]
MKEQIFDYDPAAALDGPEAIAIFISDAFETGDAEYIAKAMGVVARAKGMTELARETGLSREQLYRSFSSKGNPTLKTMLT
VMRALGVDMTARMH

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G4CV40

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4CUT8

References