Detailed information of TA system TA029393

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4561463..4561979
• Replicon: chromosome
• Accession: NC_021150
• Organism: Azotobacter vinelandii CA6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M9YJX4
• Locus tag: AVCA6_RS20495
• Protein ID: WP_012702982.1
• Coordinates: 4561463..4561744 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M9YN91
• Locus tag: AVCA6_RS20500
• Protein ID: WP_012702983.1
• Coordinates: 4561734..4561979 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVCA6_RS20475	4556505..4557155	+	651	WP_012702978.1	peptide-methionine (S)-S-oxide reductase MsrA	-
AVCA6_RS20480	4557248..4557652	-	405	WP_041807414.1	VOC family protein	-
AVCA6_RS25355	4557923..4558405	-	483	WP_012702980.1	AAA family ATPase	-
AVCA6_RS20490	4558681..4561077	-	2397	WP_012702981.1	TonB-dependent siderophore receptor	-
AVCA6_RS20495	4561463..4561744	-	282	WP_012702982.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AVCA6_RS20500	4561734..4561979	-	246	WP_012702983.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AVCA6_RS20505	4562102..4563037	-	936	WP_012702984.1	FecR family protein	-
AVCA6_RS20510	4563043..4563561	-	519	WP_012702985.1	RNA polymerase sigma factor	-
AVCA6_RS20515	4564026..4564928	-	903	WP_012702987.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
AVCA6_RS20520	4564975..4565865	-	891	WP_012702988.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-71)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10850.64 Da
• Isoelectric Point: 10.2902

>T29393 WP_012702982.1 NC_021150:c4561744-4561463 [Azotobacter vinelandii CA6]
MTYSLEFLPSALKEWEGLGHTLREQLKKKLRERLELPRVPADALRDMPNHYKIELRAAGYRLVYRVEDERVVVVVVAVGK
RERSAAYEKAKGR

Nucleotide

• Length: 282 bp

>T29393 NC_021150:c4561744-4561463 [Azotobacter vinelandii CA6]
ATGACCTATAGCCTGGAATTCCTGCCGTCCGCGCTGAAGGAGTGGGAGGGGCTGGGCCACACGTTGCGCGAGCAGTTGAA
GAAGAAACTGCGCGAGCGTCTGGAGTTGCCCAGGGTACCGGCCGATGCCCTGCGCGACATGCCGAATCACTACAAGATCG
AACTGCGCGCCGCGGGCTATCGCCTGGTGTACCGGGTAGAGGACGAGCGCGTGGTGGTGGTCGTGGTCGCTGTGGGCAAG
CGCGAACGCAGCGCGGCCTATGAGAAGGCTAAAGGACGGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8656.01 Da
• Isoelectric Point: 4.7023

>AT29393 WP_012702983.1 NC_021150:c4561979-4561734 [Azotobacter vinelandii CA6]
MQNVLADKAVSVSELKKNPSAVIGSAQGGPVAVLNHNRVMGYMVPAAVFEAMIERLEDLELAELARARANEKPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT29393 NC_021150:c4561979-4561734 [Azotobacter vinelandii CA6]
ATGCAAAACGTATTGGCCGACAAGGCCGTCAGCGTGTCCGAACTGAAAAAGAATCCGTCTGCCGTGATCGGCAGCGCCCA
AGGTGGGCCGGTAGCGGTGCTGAATCACAACCGGGTGATGGGTTACATGGTGCCGGCGGCGGTATTCGAAGCGATGATCG
AGCGCTTGGAGGACTTGGAGCTGGCCGAACTGGCTCGTGCCCGCGCCAATGAAAAGCCCGTGCCGGTGAGCCTGGATGAC
CTATAG

Structures

Toxin

• AlphaFold DB: M9YJX4

Antitoxin

• AlphaFold DB: M9YN91