Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4361226..4361837 Replicon chromosome
Accession NZ_LT963408
Organism Pseudomonas syringae group genomosp. 3 isolate CFBP6411

Toxin (Protein)


Gene name PfiT Uniprot ID A0A2S4HLU6
Locus tag C6H37_RS20950 Protein ID WP_005735311.1
Coordinates 4361487..4361837 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A3M4KYK1
Locus tag C6H37_RS20945 Protein ID WP_005735310.1
Coordinates 4361226..4361474 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H37_RS20925 4358342..4359409 + 1068 WP_104698607.1 IS630 family transposase -
C6H37_RS20930 4359435..4359803 + 369 Protein_3873 DUF2778 domain-containing protein -
C6H37_RS20935 4359803..4360132 + 330 WP_005735474.1 hypothetical protein -
C6H37_RS20940 4360328..4361065 + 738 WP_103379577.1 IS5 family transposase -
C6H37_RS20945 4361226..4361474 + 249 WP_005735310.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C6H37_RS20950 4361487..4361837 + 351 WP_005735311.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6H37_RS31005 4361943..4362239 - 297 WP_146048105.1 hypothetical protein -
C6H37_RS20960 4362644..4363003 + 360 Protein_3879 helix-turn-helix domain containing protein -
C6H37_RS20965 4363091..4363447 + 357 WP_078983211.1 IS66 family insertion sequence element accessory protein TnpB -
C6H37_RS20970 4363465..4364997 + 1533 WP_104698608.1 IS66 family transposase -
C6H37_RS20975 4365043..4365759 + 717 Protein_3882 IS630 family transposase -
C6H37_RS31310 4366453..4366692 + 240 WP_005740586.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4358678..4365759 7081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12901.70 Da        Isoelectric Point: 4.1824

>T293927 WP_005735311.1 NZ_LT963408:4361487-4361837 [Pseudomonas syringae group genomosp. 3]
MNTFALRFTDVAQQSLEDQVEHLAVTQGFSSAAQRIDTLIDAIQDKLLSTPLGYPVSPQLSELGVLHYRELNTDGYRIFY
EVMDSDGITDIAVLLVLGGKQSVEQALIRYCLLQPI

Download         Length: 351 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9359.74 Da        Isoelectric Point: 9.8452

>AT293927 WP_005735310.1 NZ_LT963408:4361226-4361474 [Pseudomonas syringae group genomosp. 3]
MRVETISYLKRNAADLPLDEPLIVTQNGVPAYVVESYADRKRRDESIALVKLLAISSREYAQGKHCSTDELKARLSRRFA
HK

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4HLU6

Antitoxin

Source ID Structure
AlphaFold DB A0A3M4KYK1

References