Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 525069..526108 Replicon chromosome
Accession NZ_LT963408
Organism Pseudomonas syringae group genomosp. 3 isolate CFBP6411

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag C6H37_RS02650 Protein ID WP_005737551.1
Coordinates 525533..526108 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A2G9KX16
Locus tag C6H37_RS02645 Protein ID WP_005737550.1
Coordinates 525069..525536 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H37_RS02630 522947..523564 + 618 WP_005737548.1 4'-phosphopantetheinyl transferase superfamily protein -
C6H37_RS02635 523659..524252 - 594 WP_005737549.1 hypothetical protein -
C6H37_RS31155 524309..524794 - 486 Protein_479 hypothetical protein -
C6H37_RS02645 525069..525536 + 468 WP_005737550.1 helix-turn-helix domain-containing protein Antitoxin
C6H37_RS02650 525533..526108 + 576 WP_005737551.1 PIN domain-containing protein Toxin
C6H37_RS02655 526289..526540 + 252 WP_005737552.1 helix-turn-helix domain-containing protein -
C6H37_RS02660 526540..527736 + 1197 WP_005737554.1 type II toxin-antitoxin system HipA family toxin -
C6H37_RS02665 527857..528141 + 285 Protein_484 N-acetylmuramoyl-L-alanine amidase -
C6H37_RS02670 528157..528906 - 750 WP_103377603.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 523659..554242 30583
- flank IS/Tn - - 528157..528906 749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21944.11 Da        Isoelectric Point: 5.5934

>T293924 WP_005737551.1 NZ_LT963408:525533-526108 [Pseudomonas syringae group genomosp. 3]
MRHSPFTAFYDANVLYPAPLRDFLMHLALTGVYRARWSSQIHDEWKRNLLINRPELTREQLDRTSALMDKAVPDGLVSDY
QSLIEGLKLPDADDRHVLAAAIKCNASVIVTFNLKDFPKDVLDTFDMEPLHPDDFIADLWDLDKAAVLEAAQRQRASLRN
PAHSARQYLDKLLQQKLPETVKLLSDFEFLI

Download         Length: 576 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17233.75 Da        Isoelectric Point: 5.2911

>AT293924 WP_005737550.1 NZ_LT963408:525069-525536 [Pseudomonas syringae group genomosp. 3]
MSSADATRTVLPGEKEIAAAVESSRQLAAFLTTKCDTQRIELVDETQQREVVELPMFALRLLGEILSELALGNAVKVVPI
HAELTTQEAADMLNVSRPHLVKMLDQGMLPHTKTGRHRRVKFADLMSYKQQRDQASREAMDELAAQAQELGMGYE

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2G9KX16

References