Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 321..868 Replicon plasmid PP3
Accession NZ_LT963405
Organism Pseudomonas syringae pv. avii isolate CFBP3846

Toxin (Protein)


Gene name mazF Uniprot ID Q48B48
Locus tag C6H38_RS30350 Protein ID WP_003319696.1
Coordinates 321..647 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H1ZWZ3
Locus tag C6H38_RS30355 Protein ID WP_015060676.1
Coordinates 644..868 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H38_RS30350 321..647 - 327 WP_003319696.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C6H38_RS30355 644..868 - 225 WP_015060676.1 antitoxin MazE family protein Antitoxin
C6H38_RS30360 1114..1749 + 636 WP_060402215.1 recombinase family protein -
C6H38_RS30370 2921..3289 + 369 WP_003348806.1 hypothetical protein -
C6H38_RS30375 3351..4013 - 663 Protein_5 Tn3 family transposase -
C6H38_RS30380 4085..4738 - 654 WP_044311043.1 type III effector HopAZ1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..108842 108842


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(8-72)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11660.71 Da        Isoelectric Point: 8.0546

>T293918 WP_003319696.1 NZ_LT963405:c647-321 [Pseudomonas syringae pv. avii]
MMRGDLVTVAMQGDFGKPRPALVIQANQFSEHTSVTVLPVTSTLVAAPLLRITVQPTAENGLQKPSQVMLDKTMTLKREK
IGPTFGHIGVDSMVEVERCLAVFLGIAN

Download         Length: 327 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8515.62 Da        Isoelectric Point: 5.5294

>AT293918 WP_015060676.1 NZ_LT963405:c868-644 [Pseudomonas syringae pv. avii]
MPTSHVNDRVQRHRDALRAAGLRPIQIWVPDTRRPDFAQECHRQCLLVAQADMANTYMQGLMDEALDDVEGWTP

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8S2J7

Antitoxin

Source ID Structure
AlphaFold DB A0A330JWK7

References