Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 36346..36920 Replicon plasmid PP1
Accession NZ_LT963403
Organism Pseudomonas syringae pv. avii isolate CFBP3846

Toxin (Protein)


Gene name vapC Uniprot ID Q88BR5
Locus tag C6H38_RS29595 Protein ID WP_011106996.1
Coordinates 36543..36920 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2K4U5C7
Locus tag C6H38_RS29590 Protein ID WP_031598125.1
Coordinates 36346..36546 (+) Length 67 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H38_RS29570 31860..32423 - 564 WP_060402321.1 hypothetical protein -
C6H38_RS29575 32444..32866 - 423 WP_060413928.1 hypothetical protein -
C6H38_RS29580 32894..35182 - 2289 WP_103379297.1 type IV secretory system conjugative DNA transfer family protein -
C6H38_RS29585 35169..36254 - 1086 WP_104698132.1 thioredoxin fold domain-containing protein -
C6H38_RS29590 36346..36546 + 201 WP_031598125.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C6H38_RS29595 36543..36920 + 378 WP_011106996.1 PIN domain-containing protein Toxin
C6H38_RS29600 36910..38112 - 1203 WP_103724603.1 conjugal transfer protein -
C6H38_RS29605 38205..38855 - 651 WP_060413746.1 plasmid IncI1-type surface exclusion protein ExcA -
C6H38_RS29610 38852..39097 - 246 WP_003344389.1 hypothetical protein -
C6H38_RS29615 39199..41343 - 2145 WP_005740374.1 DotA/TraY family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43975 43975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-113)

Antitoxin

(1-43)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13617.77 Da        Isoelectric Point: 6.0589

>T293916 WP_011106996.1 NZ_LT963403:36543-36920 [Pseudomonas syringae pv. avii]
VIGVLVDTSVWVEHFRNNSPELVNLLSQDRVLIHPMVIGELACGTPPDRLSTLTDLGDLRGAQQPTVSEVIAFLNTHKLY
GLGCGLVDMTLLASALLSGTALWTLDKRLERLASRMAVSYQPPTH

Download         Length: 378 bp


Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7430.61 Da        Isoelectric Point: 7.0102

>AT293916 WP_031598125.1 NZ_LT963403:36346-36546 [Pseudomonas syringae pv. avii]
MRTTVTIDDALYQRALEVADPAMDKADLFREAVQTFVRIQAAKRLMALGATLPAMEDIARRHEKAQ

Download         Length: 201 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q88BR5


Antitoxin

Source ID Structure
AlphaFold DB A0A2K4U5C7

References