Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1635685..1636307 Replicon chromosome
Accession NZ_LT963402
Organism Pseudomonas syringae pv. avii isolate CFBP3846

Toxin (Protein)


Gene name hicA Uniprot ID Q886E5
Locus tag C6H38_RS07965 Protein ID WP_011103638.1
Coordinates 1635685..1635867 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q886E4
Locus tag C6H38_RS07970 Protein ID WP_005767619.1
Coordinates 1635903..1636307 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H38_RS07955 1631876..1633624 - 1749 WP_005767614.1 N-acetylglutaminylglutamine synthetase -
C6H38_RS07960 1633628..1635400 - 1773 WP_060411995.1 N-acetylglutaminylglutamine amidotransferase -
C6H38_RS07965 1635685..1635867 + 183 WP_011103638.1 type II toxin-antitoxin system HicA family toxin Toxin
C6H38_RS07970 1635903..1636307 + 405 WP_005767619.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C6H38_RS07975 1636323..1637402 - 1080 WP_060411996.1 iron ABC transporter permease -
C6H38_RS07980 1637392..1639869 - 2478 WP_060411997.1 ABC transporter permease -
C6H38_RS07985 1639869..1640537 - 669 WP_060411998.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6675.81 Da        Isoelectric Point: 10.6643

>T293910 WP_011103638.1 NZ_LT963402:1635685-1635867 [Pseudomonas syringae pv. avii]
VQSRQLVKELEADGWVLDRVTGSHHMFKHPEKSQTVPVPHPKKDLPLGTVKAIRKLAGLA

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14455.52 Da        Isoelectric Point: 4.9093

>AT293910 WP_005767619.1 NZ_LT963402:1635903-1636307 [Pseudomonas syringae pv. avii]
MKYPICIEWGDETTAFGIQIPDIPGAITAGDTFEEAHAAAVEIAHIMLQEIAASGGSIPKVGTVAEHAKNPDFSGMGWGM
LEIDVTPYLGKTEKVNVTLPGFVIRQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q886E5

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3Z2W9

References