Detailed information of TA system TA029390

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 3747345..3747873
• Replicon: chromosome
• Accession: NC_021150
• Organism: Azotobacter vinelandii CA6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M9YHR5
• Locus tag: AVCA6_RS16815
• Protein ID: WP_012702214.1
• Coordinates: 3747592..3747873 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: M9YCW9
• Locus tag: AVCA6_RS16810
• Protein ID: WP_012702213.1
• Coordinates: 3747345..3747605 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVCA6_RS16785	3742893..3743441	-	549	WP_012702208.1	CDP-alcohol phosphatidyltransferase family protein	-
AVCA6_RS16790	3743487..3744491	-	1005	WP_012702209.1	DUF2066 domain-containing protein	-
AVCA6_RS16795	3744718..3745773	+	1056	WP_012702210.1	phosphoribosylformylglycinamidine cyclo-ligase	-
AVCA6_RS16800	3745773..3746420	+	648	WP_012702211.1	phosphoribosylglycinamide formyltransferase	-
AVCA6_RS16805	3746434..3747150	+	717	WP_012702212.1	DUF3108 domain-containing protein	-
AVCA6_RS16810	3747345..3747605	+	261	WP_012702213.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AVCA6_RS16815	3747592..3747873	+	282	WP_012702214.1	type II toxin-antitoxin system YafQ family toxin	Toxin
AVCA6_RS16820	3748199..3748738	-	540	WP_012702215.1	DUF2058 domain-containing protein	-
AVCA6_RS16825	3749005..3749838	-	834	WP_012702216.1	nucleoside triphosphate pyrophosphohydrolase	-
AVCA6_RS16830	3749926..3750264	-	339	WP_012702217.1	DUF3325 domain-containing protein	-
AVCA6_RS16835	3750258..3751919	-	1662	WP_012702218.1	PepSY domain-containing protein	-
AVCA6_RS16840	3751919..3752134	-	216	WP_012702219.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10724.16 Da
• Isoelectric Point: 7.0617

>T29390 WP_012702214.1 NC_021150:3747592-3747873 [Azotobacter vinelandii CA6]
VRTIKQTSQFKRDLQREAKGQHQATLEDDLLPVIEALAKDRPPDVLHRDHALTGNWVDHRDCHIKTDLVLLYRKPNDETL
QLVRLGSHSELGL

Nucleotide

• Length: 282 bp

>T29390 NC_021150:3747592-3747873 [Azotobacter vinelandii CA6]
GTGCGGACGATTAAGCAGACCAGCCAGTTCAAGCGCGACTTGCAGCGCGAAGCGAAGGGGCAGCACCAGGCGACGTTGGA
AGACGACCTGCTGCCGGTCATCGAGGCGCTGGCGAAGGATCGCCCTCCGGATGTCCTGCATCGTGACCATGCCCTGACGG
GCAACTGGGTGGATCATCGCGACTGCCACATAAAAACGGACCTGGTGTTGCTGTACCGGAAGCCGAACGACGAAACGCTG
CAATTGGTTCGCCTCGGCTCGCATAGCGAGCTGGGGCTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9395.79 Da
• Isoelectric Point: 4.4012

>AT29390 WP_012702213.1 NC_021150:3747345-3747605 [Azotobacter vinelandii CA6]
MATETTVRARIDERIKNEATVVLESMGLTMSDAIKLMLVRVAEEGRLPFAPLEPSLETIAAARAAREGNLETVTLDELRA
AIRADD

Nucleotide

• Length: 261 bp

>AT29390 NC_021150:3747345-3747605 [Azotobacter vinelandii CA6]
ATGGCCACCGAAACGACCGTCCGCGCCCGCATCGACGAGCGCATCAAGAATGAAGCCACCGTGGTGCTCGAATCCATGGG
CCTGACCATGTCGGACGCCATCAAGCTGATGCTGGTGCGCGTCGCCGAGGAAGGGCGCTTGCCGTTCGCGCCGCTGGAGC
CCTCCCTGGAAACCATCGCGGCTGCACGTGCAGCACGCGAGGGGAACCTCGAAACCGTGACCCTGGACGAGCTGCGGGCG
GCGATTCGTGCGGACGATTAA

Structures

Toxin

• AlphaFold DB: M9YHR5

Antitoxin

• AlphaFold DB: M9YCW9