Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4195752..4196374 Replicon chromosome
Accession NZ_LT963395
Organism Pseudomonas cerasi isolate PL963

Toxin (Protein)


Gene name hicA Uniprot ID A0A658PBH1
Locus tag C6H34_RS19410 Protein ID WP_003434313.1
Coordinates 4196192..4196374 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A193SSY5
Locus tag C6H34_RS19405 Protein ID WP_024661723.1
Coordinates 4195752..4196156 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H34_RS19390 4191518..4192186 + 669 WP_065350359.1 ABC transporter ATP-binding protein -
C6H34_RS19395 4192186..4194666 + 2481 WP_065350360.1 ABC transporter permease -
C6H34_RS19400 4194656..4195735 + 1080 WP_065350361.1 iron ABC transporter permease -
C6H34_RS19405 4195752..4196156 - 405 WP_024661723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C6H34_RS19410 4196192..4196374 - 183 WP_003434313.1 type II toxin-antitoxin system HicA family toxin Toxin
C6H34_RS19415 4196658..4198430 + 1773 WP_024661722.1 N-acetylglutaminylglutamine amidotransferase -
C6H34_RS19420 4198434..4200182 + 1749 WP_024661721.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6777.99 Da        Isoelectric Point: 10.6643

>T293897 WP_003434313.1 NZ_LT963395:c4196374-4196192 [Pseudomonas cerasi]
VQSRQLIKELEADGWILDRVSGSHHMFKHPEKLQTVPVPHPKKDLPFGTVRAIKKLAGLV

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14345.43 Da        Isoelectric Point: 5.1643

>AT293897 WP_024661723.1 NZ_LT963395:c4196156-4195752 [Pseudomonas cerasi]
MKYPMCIEWGSETTAFGIQIPDIPGAVTAGDTFEEAHAAAVEIAHIMLQEIAAGGGTIPKAGTVAEHARNADFAGMGWGM
IEIDVTPYLGKTEKVNVTLPGFVIKQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A658PBH1

Antitoxin

Source ID Structure
AlphaFold DB A0A193SSY5

References