Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1472581..1473112 Replicon chromosome
Accession NZ_LT962688
Organism Methylorubrum extorquens strain TK 0001

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag TK0001_RS06915 Protein ID WP_003605878.1
Coordinates 1472581..1472862 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C5B2A4
Locus tag TK0001_RS06920 Protein ID WP_003605879.1
Coordinates 1472849..1473112 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TK0001_RS06890 1469159..1469989 + 831 WP_101475551.1 nucleoside triphosphate pyrophosphohydrolase -
TK0001_RS06895 1470127..1470318 - 192 WP_056501144.1 hypothetical protein -
TK0001_RS06900 1470407..1470829 - 423 WP_101475552.1 DoxX family protein -
TK0001_RS06905 1470836..1471021 - 186 WP_003605874.1 hypothetical protein -
TK0001_RS06910 1471118..1472464 - 1347 WP_056501131.1 30S ribosomal protein S12 methylthiotransferase RimO -
TK0001_RS06915 1472581..1472862 - 282 WP_003605878.1 type II toxin-antitoxin system YafQ family toxin Toxin
TK0001_RS06920 1472849..1473112 - 264 WP_003605879.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
TK0001_RS06925 1473405..1474805 + 1401 WP_056501127.1 aminodeoxychorismate synthase component I -
TK0001_RS06930 1474802..1475431 + 630 WP_056501123.1 aminodeoxychorismate/anthranilate synthase component II -
TK0001_RS06935 1475418..1476275 + 858 WP_101475553.1 aminotransferase class IV -
TK0001_RS06940 1476445..1477071 - 627 WP_056153177.1 bifunctional nicotinamidase/pyrazinamidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10664.24 Da        Isoelectric Point: 10.2159

>T293864 WP_003605878.1 NZ_LT962688:c1472862-1472581 [Methylorubrum extorquens]
MRTIERTTQFKRDYKREMKGRHRASLQADLTAVLTELAADRPLAARLRDHALTGNWADHRDCHVKPDLVLIYRLAGTETL
QLVRLGSHAELGF

Download         Length: 282 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9356.81 Da        Isoelectric Point: 4.4230

>AT293864 WP_003605879.1 NZ_LT962688:c1473112-1472849 [Methylorubrum extorquens]
MPTKSLIQARIDADTKEEATAVLKAMGLTVSDAVRMMLVRVAREKALPFEPLVPNETTIAAIREARSGNLPGFTSVEALM
ADLDADD

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB C5B2A4

References