Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 5213867..5214408 Replicon chromosome
Accession NZ_LT960614
Organism Hartmannibacter diazotrophicus strain E19T

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HDIA_RS23975 Protein ID WP_099558521.1
Coordinates 5213867..5214190 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HDIA_RS23980 Protein ID WP_099558522.1
Coordinates 5214187..5214408 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HDIA_RS23955 5210478..5210999 - 522 WP_099558517.1 FixH family protein -
HDIA_RS23960 5211125..5212573 - 1449 WP_099558518.1 cytochrome c oxidase accessory protein CcoG -
HDIA_RS23965 5212962..5213489 + 528 WP_099558519.1 peptide-methionine (R)-S-oxide reductase MsrB -
HDIA_RS23970 5213498..5213833 - 336 WP_099558520.1 hypothetical protein -
HDIA_RS23975 5213867..5214190 - 324 WP_099558521.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HDIA_RS23980 5214187..5214408 - 222 WP_099558522.1 antitoxin MazE family protein Antitoxin
HDIA_RS23985 5214502..5215086 - 585 WP_099558523.1 NAD(P)H-dependent oxidoreductase -
HDIA_RS23990 5215218..5216090 - 873 WP_099558524.1 cytochrome-c oxidase, cbb3-type subunit III -
HDIA_RS23995 5216094..5216249 - 156 WP_099558525.1 cbb3-type cytochrome c oxidase subunit 3 -
HDIA_RS24000 5216260..5216994 - 735 WP_099558526.1 cytochrome-c oxidase, cbb3-type subunit II -
HDIA_RS24005 5217006..5218628 - 1623 WP_099558527.1 cytochrome-c oxidase, cbb3-type subunit I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(6-67)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11630.62 Da        Isoelectric Point: 10.2912

>T293858 WP_099558521.1 NZ_LT960614:c5214190-5213867 [Hartmannibacter diazotrophicus]
MRRGDLVTVAISGDFGKPRPALIVQSDQFEASATVTVLLLSGTLIDAPLIRIRVDPTPENGLNKPSQIMIDKIMTVRREK
LSAPFGRLDNDLLVAVNRSLALFLGFG

Download         Length: 324 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8141.11 Da        Isoelectric Point: 4.4367

>AT293858 WP_099558522.1 NZ_LT960614:c5214408-5214187 [Hartmannibacter diazotrophicus]
MPSSVNERVERRRQALRAAGLRPIQIWVPDNRRPGFADECRRQALLAAQSDAADAELTDILDTALAELAEPEE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References