Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_31(antitoxin)
Location 4117178..4118420 Replicon chromosome
Accession NZ_LT960614
Organism Hartmannibacter diazotrophicus strain E19T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HDIA_RS19205 Protein ID WP_099557629.1
Coordinates 4117839..4118420 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HDIA_RS19200 Protein ID WP_099557628.1
Coordinates 4117178..4117750 (+) Length 191 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HDIA_RS19180 4112411..4114183 - 1773 WP_099557625.1 adenylate/guanylate cyclase domain-containing protein -
HDIA_RS19185 4114273..4114905 - 633 WP_099559017.1 hypothetical protein -
HDIA_RS19190 4115221..4115982 - 762 WP_157775738.1 DUF1223 domain-containing protein -
HDIA_RS25465 4115975..4116184 - 210 WP_157775739.1 hypothetical protein -
HDIA_RS19195 4116240..4117121 + 882 WP_099557627.1 EamA family transporter -
HDIA_RS19200 4117178..4117750 + 573 WP_099557628.1 helix-turn-helix domain-containing protein Antitoxin
HDIA_RS19205 4117839..4118420 + 582 WP_099557629.1 HD domain-containing protein Toxin
HDIA_RS19210 4118461..4118892 - 432 WP_099557630.1 cupin domain-containing protein -
HDIA_RS19215 4118896..4119666 - 771 WP_099557631.1 hydroxyacylglutathione hydrolase -
HDIA_RS19220 4119897..4120715 + 819 WP_099557632.1 class I SAM-dependent methyltransferase -
HDIA_RS19225 4120866..4121651 + 786 WP_099559018.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(23-177)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-62)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21483.22 Da        Isoelectric Point: 4.6592

>T293857 WP_099557629.1 NZ_LT960614:4117839-4118420 [Hartmannibacter diazotrophicus]
MNAHDTPEKARIAGILDFIQAAENLKNTLRSGTTSNGRAESTAEHSWRLCLLVLMFDRDLGDCDRLKLLKLCIVHDLGEA
ISGDVPPILQVEGDGRAERERADLETLCAPLPQDLRDDILALWDDYNTASSPEAVLAKGFDKLETMLQHNVGKNPADFDY
EFNLGYGVKQTDAHPLLRAIRTLVDEETRRRAG

Download         Length: 582 bp

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 20933.41 Da        Isoelectric Point: 10.2674

>AT293857 WP_099557628.1 NZ_LT960614:4117178-4117750 [Hartmannibacter diazotrophicus]
MTTLPLYPKPLGSALRRWRTLNRVKQAALAETLGVSQTTVCRWESGAVMPSPQQVRHLSKLLTARPEAAADKALLDLVAM
AHEPVHLVCDLTHRLLAASPARMATWRIPLADLLGVSLWRFASEGIRAGETRLEEAGWYKPVAPALTIMTERAEFPELTI
RAGEIRLARIPLSDGSYARLVRDGARIGPE

Download         Length: 573 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References