Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 49111..50459 | Replicon | plasmid P |
| Accession | NZ_LT960613 | ||
| Organism | Vibrio tapetis subsp. tapetis isolate Vibrio tapetis CECT4600 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | B2LS98 |
| Locus tag | VTAP4600_RS25590 | Protein ID | WP_012397035.1 |
| Coordinates | 49518..50459 (+) | Length | 314 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | B2LS97 |
| Locus tag | VTAP4600_RS25585 | Protein ID | WP_012397034.1 |
| Coordinates | 49111..49515 (+) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VTAP4600_RS25560 | 44552..46084 | + | 1533 | WP_102521770.1 | IS21 family transposase | - |
| VTAP4600_RS25565 | 46094..46834 | + | 741 | WP_012397030.1 | IS21-like element helper ATPase IstB | - |
| VTAP4600_RS25570 | 46979..47446 | + | 468 | WP_012397031.1 | hypothetical protein | - |
| VTAP4600_RS25575 | 47578..48066 | + | 489 | WP_131825470.1 | hypothetical protein | - |
| VTAP4600_RS25580 | 48330..48923 | + | 594 | WP_012397033.1 | tyrosine-type recombinase/integrase | - |
| VTAP4600_RS25585 | 49111..49515 | + | 405 | WP_012397034.1 | hypothetical protein | Antitoxin |
| VTAP4600_RS25590 | 49518..50459 | + | 942 | WP_012397035.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| VTAP4600_RS25595 | 50467..53061 | + | 2595 | WP_012397036.1 | type I restriction-modification system subunit M | - |
| VTAP4600_RS25600 | 53054..54313 | + | 1260 | WP_012397037.1 | restriction endonuclease subunit S | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..82266 | 82266 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 314 a.a. Molecular weight: 36177.99 Da Isoelectric Point: 5.5269
>T293855 WP_012397035.1 NZ_LT960613:49518-50459 [Vibrio tapetis subsp. tapetis]
MKKLKQQFLEVSDALALGNPAIIEKDYWVVALLAELEKLTFETHQLVFAGGTALAKSNVKILRMSEDVDIKLIPSKEFDA
LSRGKKKTARKMLIEQIEQVIARSQQFTVESRLVRDEYRYVEYELKYPQQFNQAPCLRPIIKLELMETIPLLEVEDRGIQ
SLVAELYKQPQEVSAFACVSVYATLVEKVLSMLRRTMLVKRDTERKDDVTLVRHIYDVHCIDTAQTLDIESLTSLFLTVL
KEDIDRFGNQHAEFVAAPIKELRLGLQELEDNPIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAESLIKTI
MKKLKQQFLEVSDALALGNPAIIEKDYWVVALLAELEKLTFETHQLVFAGGTALAKSNVKILRMSEDVDIKLIPSKEFDA
LSRGKKKTARKMLIEQIEQVIARSQQFTVESRLVRDEYRYVEYELKYPQQFNQAPCLRPIIKLELMETIPLLEVEDRGIQ
SLVAELYKQPQEVSAFACVSVYATLVEKVLSMLRRTMLVKRDTERKDDVTLVRHIYDVHCIDTAQTLDIESLTSLFLTVL
KEDIDRFGNQHAEFVAAPIKELRLGLQELEDNPIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAESLIKTI
Download Length: 942 bp
Antitoxin
Download Length: 135 a.a. Molecular weight: 15197.34 Da Isoelectric Point: 10.5757
>AT293855 WP_012397034.1 NZ_LT960613:49111-49515 [Vibrio tapetis subsp. tapetis]
MTAADRIYQNIKRSRRYVFERKDFDGFASYDQVGRALRQLVKQGELMKLGYGLYTKARVNSLTGRPMPTNPGGSDALIRE
ILKMKGVDFEMDSLSLQSFSGESTQVPSSVHYSWNPKQFNRKLVVGNRVLNSPS
MTAADRIYQNIKRSRRYVFERKDFDGFASYDQVGRALRQLVKQGELMKLGYGLYTKARVNSLTGRPMPTNPGGSDALIRE
ILKMKGVDFEMDSLSLQSFSGESTQVPSSVHYSWNPKQFNRKLVVGNRVLNSPS
Download Length: 405 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N8ZHR3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2N8ZHQ5 |