Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2020405..2021000 Replicon chromosome
Accession NZ_LT934425
Organism Candidatus Kuenenia stuttgartiensis isolate kuenenia_mbr1_ru-nijmegen

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KSMBR1_RS09285 Protein ID WP_099325074.1
Coordinates 2020740..2021000 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KSMBR1_RS09280 Protein ID WP_099325073.1
Coordinates 2020405..2020743 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSMBR1_RS09265 2017596..2018048 - 453 WP_099325071.1 Hsp20/alpha crystallin family protein -
KSMBR1_RS09275 2018243..2019880 - 1638 WP_099327020.1 chaperonin GroEL -
KSMBR1_RS09280 2020405..2020743 - 339 WP_099325073.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSMBR1_RS09285 2020740..2021000 - 261 WP_099325074.1 type II toxin-antitoxin system HicA family toxin Toxin
KSMBR1_RS09290 2021101..2022180 - 1080 WP_099325075.1 ABC transporter ATP-binding protein -
KSMBR1_RS09295 2022177..2022884 - 708 WP_157820503.1 carbohydrate ABC transporter permease -
KSMBR1_RS09300 2023423..2024199 + 777 WP_099325077.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9890.48 Da        Isoelectric Point: 10.4214

>T293840 WP_099325074.1 NZ_LT934425:c2021000-2020740 [Candidatus Kuenenia stuttgartiensis]
MSKAEKLLRRFLSKPKDFTYDDLKSLLAGFGYEKAKSGKTTGSGVTFINPETRHIIRLHKPHPGVELKRYQLDYIEEALR
NKGLIQ

Download         Length: 261 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12582.42 Da        Isoelectric Point: 7.0617

>AT293840 WP_099325073.1 NZ_LT934425:c2020743-2020405 [Candidatus Kuenenia stuttgartiensis]
MKDVLTYKGFTGTVHFSAEDKVFHGKIEGIDDLVIFEGHSVEELVKAFHNAADDYAALCREMGKVPIKSYRGSFNVRIPP
EMHRKAAERAIQKGLSLNQLVQTAIEKELVHN

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References