Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 870824..872649 Replicon chromosome
Accession NZ_LT907989
Organism Vibrio cholerae strain A19

Toxin (Protein)


Gene name hipA Uniprot ID A0A0K9UVP8
Locus tag ALC86_RS04215 Protein ID WP_000392003.1
Coordinates 871288..872649 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ALC86_RS04210 Protein ID WP_000804849.1
Coordinates 870824..871291 (-) Length 156 a.a.

Genomic Context

ALC86_RS04225ALC86_RS04195ALC86_RS04200ALC86_RS04205ALC86_RS04210ALC86_RS04215ALC86_RS04230ALC86_RS04235
Location: 873253..874230 (978 bp)
Type: Others
Protein ID: WP_001889101.1
Location: 866104..866808 (705 bp)
Type: Others
Protein ID: WP_001880605.1
Location: 866878..869814 (2937 bp)
Type: Others
Protein ID: WP_001283872.1
Location: 869818..870396 (579 bp)
Type: Others
Protein ID: WP_000109982.1
Location: 870824..871291 (468 bp)
Type: Antitoxin
Protein ID: WP_000804849.1
Location: 871288..872649 (1362 bp)
Type: Toxin
Protein ID: WP_000392003.1
Location: 874256..874936 (681 bp)
Type: Others
Protein ID: Protein_750
Location: 875278..876798 (1521 bp)
Type: Others
Protein ID: WP_000640055.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ALC86_RS04195866104..866808-705WP_001880605.1NERD domain-containing protein-
ALC86_RS04200866878..869814-2937WP_001283872.1DEAD/DEAH box helicase family protein-
ALC86_RS04205869818..870396-579WP_000109982.1class I SAM-dependent methyltransferase-
ALC86_RS04210870824..871291-468WP_000804849.1helix-turn-helix domain-containing proteinAntitoxin
ALC86_RS04215871288..872649-1362WP_000392003.1type II toxin-antitoxin system HipA family toxinToxin
ALC86_RS04225873253..874230+978WP_001889101.1IS481-like element ISVch1 family transposase-
ALC86_RS04230874256..874936-681Protein_750IS5 family transposase-
ALC86_RS04235875278..876798-1521WP_000640055.1aldehyde dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51246.17 Da        Isoelectric Point: 4.9109

>T293820 WP_000392003.1 NZ_LT907989:c872649-871288 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSSHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17095.51 Da        Isoelectric Point: 10.6157

>AT293820 WP_000804849.1 NZ_LT907989:c871291-870824 [Vibrio cholerae]
MKPSNKESVQDTVARLRENRNQQQSKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UVP8

Antitoxin

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Source
ID
Structure
No matching records found

References