Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 4733188..4733771 Replicon chromosome
Accession NC_021149
Organism Azotobacter vinelandii CA

Toxin (Protein)


Gene name vapC Uniprot ID M9YMQ6
Locus tag AVCA_RS21270 Protein ID WP_012703131.1
Coordinates 4733391..4733771 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M9YNF6
Locus tag AVCA_RS21265 Protein ID WP_012703130.1
Coordinates 4733188..4733394 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVCA_RS21245 4728867..4730201 + 1335 WP_012703124.1 HAMP domain-containing protein -
AVCA_RS21250 4730545..4731303 + 759 WP_012703126.1 TorF family putative porin -
AVCA_RS21255 4731558..4732355 - 798 WP_012703127.1 4-hydroxy-2-oxoheptanedioate aldolase -
AVCA_RS21260 4732501..4732953 + 453 WP_012703128.1 GNAT family N-acetyltransferase -
AVCA_RS21265 4733188..4733394 + 207 WP_012703130.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AVCA_RS21270 4733391..4733771 + 381 WP_012703131.1 PIN domain-containing protein Toxin
AVCA_RS21275 4734164..4735642 - 1479 WP_012703132.1 anthranilate synthase component I -
AVCA_RS21280 4735829..4736482 - 654 WP_072432469.1 phosphoglycolate phosphatase -
AVCA_RS21285 4736527..4737201 - 675 WP_012703134.1 ribulose-phosphate 3-epimerase -
AVCA_RS21290 4737299..4738579 - 1281 WP_012703135.1 4-aminobutyrate--2-oxoglutarate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13873.21 Da        Isoelectric Point: 6.7009

>T29382 WP_012703131.1 NC_021149:4733391-4733771 [Azotobacter vinelandii CA]
MKVLVDTSVWIDHFRNGNAALVELLGSDDALTHPMVIAEIACGTPPAPRAQTLDNLGLLQSCRQATLQEVMTFIEREKLY
GLGCGLVDIALLASTLITPGTLLWTLDKRLASLARRFDVAYRPMRH

Download         Length: 381 bp

>T29382 NC_021149:4733391-4733771 [Azotobacter vinelandii CA]
ATGAAAGTGCTGGTCGACACATCGGTGTGGATCGACCACTTTCGCAATGGCAACGCCGCGCTGGTCGAACTGCTCGGCTC
GGACGACGCCCTGACCCACCCCATGGTCATCGCCGAAATCGCCTGTGGTACACCGCCGGCTCCACGCGCCCAGACACTGG
ATAACCTGGGGCTGTTGCAATCCTGCAGACAGGCGACCCTGCAGGAAGTCATGACGTTCATCGAGCGGGAAAAACTCTAT
GGCCTGGGGTGCGGGCTGGTGGATATAGCTCTGCTGGCATCGACGCTCATCACGCCGGGGACACTGCTATGGACGCTGGA
CAAGCGCCTGGCAAGCCTGGCTCGGCGTTTCGATGTCGCCTATCGCCCGATGAGGCACTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7703.86 Da        Isoelectric Point: 10.5812

>AT29382 WP_012703130.1 NC_021149:4733188-4733394 [Azotobacter vinelandii CA]
MRTTVTIDDALYEKALEMADPGMDKADIFREAMKTFVRVQAARRLAALGGTTPNVRNVPRRRERAEPQ

Download         Length: 207 bp

>AT29382 NC_021149:4733188-4733394 [Azotobacter vinelandii CA]
ATGCGCACCACCGTCACTATCGATGACGCGCTCTATGAAAAGGCTCTCGAAATGGCCGATCCGGGCATGGACAAGGCGGA
CATCTTCCGCGAGGCCATGAAGACCTTCGTGCGGGTTCAAGCCGCCAGACGCCTCGCGGCGCTGGGAGGAACCACGCCGA
ACGTCCGGAACGTGCCTCGCCGTCGGGAGAGAGCCGAGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M9YMQ6

Antitoxin

Source ID Structure
AlphaFold DB M9YNF6

References