Detailed information of TA system TA293815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 3416547..3417118
• Replicon: chromosome
• Accession: NZ_LT907988
• Organism: Orrella dioscoreae isolate Orrdi1

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: ODI_RS15900
• Protein ID: WP_067755683.1
• Coordinates: 3416547..3416768 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: ODI_RS15905
• Protein ID: WP_067755710.1
• Coordinates: 3416825..3417118 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ODI_RS15885	3412496..3413488	+	993	WP_067755713.1	tripartite tricarboxylate transporter substrate binding protein	-
ODI_RS15890	3413569..3414528	+	960	WP_067755689.1	2-hydroxyacid dehydrogenase	-
ODI_RS15895	3414895..3416550	+	1656	WP_067755686.1	Tar ligand binding domain-containing protein	-
ODI_RS15900	3416547..3416768	+	222	WP_067755683.1	addiction module protein	Toxin
ODI_RS15905	3416825..3417118	+	294	WP_067755710.1	putative addiction module antidote protein	Antitoxin
ODI_RS15910	3417286..3417867	+	582	WP_067755681.1	hypothetical protein	-
ODI_RS15915	3418054..3418419	+	366	WP_067755678.1	hypothetical protein	-
ODI_RS15920	3418578..3418841	+	264	WP_067755675.1	hypothetical protein	-
ODI_RS15925	3419016..3419330	-	315	WP_157929776.1	hypothetical protein	-
ODI_RS15930	3419627..3420796	+	1170	WP_067755670.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-73)

Antitoxin

• Cro/C1-type helix-turn-helix domain (48-95)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8002.11 Da
• Isoelectric Point: 9.5600

>T293815 WP_067755683.1 NZ_LT907988:3416547-3416768 [Orrella dioscoreae]
MNQARVQRLALGNPGDHRGLQHGVKELRIHVGPGYRVYYTERDTNTLVVLLAGGDKSTQQADIALAYLLATSL

Nucleotide

• Length: 222 bp

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10624.17 Da
• Isoelectric Point: 7.1656

>AT293815 WP_067755710.1 NZ_LT907988:3416825-3417118 [Orrella dioscoreae]
MPKTSTRPYDVAEHLRTPREMALYLDACIEESDGDAAFIAKALGDVARAQGMSKVARETGLSRESLYKSLSGEREPDFST
VLKVLKALGIRFHAIPA

Nucleotide

• Length: 294 bp