Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2190258..2190881 Replicon chromosome
Accession NZ_LT907978
Organism Anaerobutyricum hallii isolate EH1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EHLA_RS10010 Protein ID WP_096240713.1
Coordinates 2190258..2190446 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EHLA_RS10015 Protein ID WP_096240714.1
Coordinates 2190492..2190881 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHLA_RS16425 2185960..2186127 - 168 WP_173854288.1 hypothetical protein -
EHLA_RS10000 2186433..2187890 + 1458 WP_096239442.1 transposase -
EHLA_RS10005 2188457..2189689 - 1233 WP_096240712.1 hypothetical protein -
EHLA_RS16260 2189875..2190033 - 159 WP_157908579.1 hypothetical protein -
EHLA_RS10010 2190258..2190446 + 189 WP_096240713.1 type II toxin-antitoxin system HicA family toxin Toxin
EHLA_RS10015 2190492..2190881 + 390 WP_096240714.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EHLA_RS10020 2191137..2192549 - 1413 WP_096240715.1 oxaloacetate decarboxylase subunit alpha -
EHLA_RS10025 2192622..2193746 - 1125 WP_005349917.1 sodium ion-translocating decarboxylase subunit beta -
EHLA_RS10030 2193780..2194148 - 369 WP_096240716.1 biotin/lipoyl-binding protein -
EHLA_RS10035 2194253..2194600 - 348 WP_096240717.1 OadG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2154116..2190881 36765
- flank IS/Tn - - 2186433..2187890 1457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-87)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7003.45 Da        Isoelectric Point: 11.1455

>T293811 WP_096240713.1 NZ_LT907978:2190258-2190446 [Anaerobutyricum hallii]
MPMKPQEMIRLLKKNGFIKISQNGSHVKMKNFKTGKQTTVPLHSKDLKKGLEDAILKQAGLK

Download         Length: 189 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 15005.08 Da        Isoelectric Point: 4.4926

>AT293811 WP_096240714.1 NZ_LT907978:2190492-2190881 [Anaerobutyricum hallii]
MKKLFYPAVFHIAEEGGYWVTFPDFPECLTQGENMQEAYDMAIDALGLILTDDINDRKELPEPSNITHVDDGVVVIIPYD
YLEYNRKYHNKSIKKTLTIPEWLNNEALRLNLNFSQILQDALLNKIQSR

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References