Detailed information of TA system TA293791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 870824..872649
• Replicon: chromosome
• Accession: NZ_LT906614
• Organism: Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0K9UVP8
• Locus tag: FY484_RS04220
• Protein ID: WP_000392003.1
• Coordinates: 871288..872649 (-)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FY484_RS04215
• Protein ID: WP_000804849.1
• Coordinates: 870824..871291 (-)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY484_RS04200	866104..866808	-	705	WP_001880605.1	NERD domain-containing protein	-
FY484_RS04205	866878..869814	-	2937	WP_001283872.1	DEAD/DEAH box helicase family protein	-
FY484_RS04210	869818..870396	-	579	WP_000109982.1	class I SAM-dependent methyltransferase	-
FY484_RS04215	870824..871291	-	468	WP_000804849.1	helix-turn-helix domain-containing protein	Antitoxin
FY484_RS04220	871288..872649	-	1362	WP_000392003.1	type II toxin-antitoxin system HipA family toxin	Toxin
FY484_RS04230	873253..874230	+	978	WP_001889101.1	IS481-like element ISVch1 family transposase	-
FY484_RS04235	874256..874936	-	681	Protein_750	IS5 family transposase	-
FY484_RS04240	875278..876798	-	1521	WP_000640055.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-383)

Antitoxin

• Cro/C1-type helix-turn-helix domain (80-138)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51246.17 Da
• Isoelectric Point: 4.9109

>T293791 WP_000392003.1 NZ_LT906614:c872649-871288 [Vibrio cholerae O1 biovar El Tor str. N16961]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSSHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Nucleotide

• Length: 1362 bp

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17095.51 Da
• Isoelectric Point: 10.6157

>AT293791 WP_000804849.1 NZ_LT906614:c871291-870824 [Vibrio cholerae O1 biovar El Tor str. N16961]
MKPSNKESVQDTVARLRENRNQQQSKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Nucleotide

• Length: 468 bp

Structures

Toxin

• AlphaFold DB: A0A0K9UVP8