Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2980997..2982596 Replicon chromosome
Accession NZ_LT906484
Organism Bordetella pertussis strain NCTC13667

Toxin (Protein)


Gene name hipA Uniprot ID Q7VVM6
Locus tag CKW08_RS14460 Protein ID WP_003816876.1
Coordinates 2981256..2982596 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CKW08_RS14455 Protein ID WP_019247974.1
Coordinates 2980997..2981254 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW08_RS14435 2976660..2977271 - 612 WP_010931041.1 DUF2239 family protein -
CKW08_RS14440 2977494..2978954 + 1461 WP_003812368.1 IMP dehydrogenase -
CKW08_RS14445 2979051..2980643 + 1593 WP_010931040.1 glutamine-hydrolyzing GMP synthase -
CKW08_RS14455 2980997..2981254 + 258 WP_019247974.1 helix-turn-helix domain-containing protein Antitoxin
CKW08_RS14460 2981256..2982596 + 1341 WP_003816876.1 type II toxin-antitoxin system HipA family toxin Toxin
CKW08_RS14465 2982692..2983381 - 690 WP_010931038.1 TetR/AcrR family transcriptional regulator -
CKW08_RS14470 2983394..2984824 + 1431 WP_019247976.1 MFS transporter -
CKW08_RS14475 2985056..2986134 + 1079 Protein_2818 tellurite resistance/C4-dicarboxylate transporter family protein -
CKW08_RS14480 2986549..2987370 + 822 WP_014905903.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49632.79 Da        Isoelectric Point: 7.4158

>T293786 WP_003816876.1 NZ_LT906484:2981256-2982596 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Download         Length: 1341 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8815.04 Da        Isoelectric Point: 7.1642

>AT293786 WP_019247974.1 NZ_LT906484:2980997-2981254 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7VVM6

Antitoxin

Source ID Structure

References