Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 112466..114049 Replicon chromosome
Accession NZ_LT906480
Organism Stenotrophomonas maltophilia strain NCTC10257

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CKW06_RS00505 Protein ID WP_038646246.1
Coordinates 112466..113788 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CKW06_RS00510 Protein ID WP_005407534.1
Coordinates 113792..114049 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW06_RS00490 107860..109494 - 1635 WP_005407530.1 TldD/PmbA family protein -
CKW06_RS00495 109525..111156 - 1632 WP_024956315.1 TldD/PmbA family protein -
CKW06_RS00500 111851..112465 + 615 WP_038646249.1 DUF938 domain-containing protein -
CKW06_RS00505 112466..113788 - 1323 WP_038646246.1 type II toxin-antitoxin system HipA family toxin Toxin
CKW06_RS00510 113792..114049 - 258 WP_005407534.1 helix-turn-helix transcriptional regulator Antitoxin
CKW06_RS00515 114211..117897 - 3687 WP_024956262.1 indolepyruvate ferredoxin oxidoreductase family protein -
CKW06_RS00520 118069..118704 + 636 WP_024956261.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49039.94 Da        Isoelectric Point: 6.9606

>T293782 WP_038646246.1 NZ_LT906480:c113788-112466 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9584.97 Da        Isoelectric Point: 11.8468

>AT293782 WP_005407534.1 NZ_LT906480:c114049-113792 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References