Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4880938..4881677 Replicon chromosome
Accession NZ_LT906479
Organism Serratia ficaria strain NCTC12148

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CKW09_RS22910 Protein ID WP_095099675.1
Coordinates 4881198..4881677 (+) Length 160 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A240CCP7
Locus tag CKW09_RS22905 Protein ID WP_061798971.1
Coordinates 4880938..4881201 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW09_RS22885 4877018..4877698 + 681 WP_095099668.1 GMP/IMP nucleotidase -
CKW09_RS22890 4877695..4878102 + 408 WP_061798964.1 ribosome-associated heat shock protein Hsp15 -
CKW09_RS22895 4878128..4879006 + 879 WP_061798966.1 Hsp33 family molecular chaperone HslO -
CKW09_RS22900 4879193..4880812 + 1620 WP_095099672.1 phosphoenolpyruvate carboxykinase (ATP) -
CKW09_RS22905 4880938..4881201 + 264 WP_061798971.1 hypothetical protein Antitoxin
CKW09_RS22910 4881198..4881677 + 480 WP_095099675.1 type II toxin-antitoxin system VapC family toxin Toxin
CKW09_RS22915 4881700..4883070 - 1371 WP_061798975.1 two-component system sensor histidine kinase EnvZ -
CKW09_RS22920 4883067..4883786 - 720 WP_004709363.1 two-component system response regulator OmpR -
CKW09_RS22925 4884097..4884411 - 315 WP_061798977.1 chaperone-modulator protein CbpM -
CKW09_RS22930 4884414..4885364 - 951 WP_095099678.1 curved DNA-binding protein -
CKW09_RS22935 4885595..4886068 + 474 WP_061798982.1 transcription elongation factor GreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17854.53 Da        Isoelectric Point: 6.4742

>T293781 WP_095099675.1 NZ_LT906479:4881198-4881677 [Serratia ficaria]
MIILDTNVMSETLRPSPHYNVINWLNEKDNDELYLSAIVIAELFNGAACMPDGKRQRDLKLKLADAIQLKFEGQTLPFDG
LCAMQYAELTARNRLQGKLMSVPDAQIAATCLHYGAALATRNSKNFLHCGIELIDPWQAPAGRRLHEDAAEYYVMSRKS

Download         Length: 480 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9813.12 Da        Isoelectric Point: 4.8500

>AT293781 WP_061798971.1 NZ_LT906479:4880938-4881201 [Serratia ficaria]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARTILKQALVKKPPRYGLGTWMHQHFAEFGGVELDIPPRDAVPPRIVSF
DDEDDNA

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A240CCP7

References