Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 4259367..4260090 Replicon chromosome
Accession NZ_LT906479
Organism Serratia ficaria strain NCTC12148

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CKW09_RS20060 Protein ID WP_095099094.1
Coordinates 4259367..4259753 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CKW09_RS20065 Protein ID WP_046899002.1
Coordinates 4259746..4260090 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW09_RS20040 4254961..4256223 + 1263 WP_095099091.1 cysteine desulfurase-like protein -
CKW09_RS20050 4256476..4257993 - 1518 WP_061796927.1 lysine--tRNA ligase -
CKW09_RS20060 4259367..4259753 + 387 WP_095099094.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKW09_RS20065 4259746..4260090 + 345 WP_046899002.1 helix-turn-helix domain-containing protein Antitoxin
CKW09_RS20070 4260142..4261875 - 1734 WP_095099097.1 single-stranded-DNA-specific exonuclease RecJ -
CKW09_RS20075 4261882..4262598 - 717 WP_061796933.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CKW09_RS20080 4262627..4263526 - 900 WP_095100284.1 site-specific tyrosine recombinase XerD -
CKW09_RS20085 4263633..4264151 + 519 WP_061796935.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(54-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14621.64 Da        Isoelectric Point: 8.4849

>T293778 WP_095099094.1 NZ_LT906479:4259367-4259753 [Serratia ficaria]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELEHGNHDGDLGGGVYKKRLPLNRGKRGGARSIVAFKHGRHQYFVDGWLKNT
VKQNGAKEINDDELATYRELAKDFLAMPPEIIKRAIDSGYLREVKCDD

Download         Length: 387 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12927.88 Da        Isoelectric Point: 10.9886

>AT293778 WP_046899002.1 NZ_LT906479:4259746-4260090 [Serratia ficaria]
MTDNRLLRLQKMAQRFNEIGAVSDDTMRSIDARVQAQEQNAQHEQREQMDGARIKMLRKRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGSALRMLEIIEQKGVASLIIPPRN

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References