Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3160479..3161110 Replicon chromosome
Accession NZ_LT906479
Organism Serratia ficaria strain NCTC12148

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CKW09_RS14990 Protein ID WP_019452963.1
Coordinates 3160479..3160877 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A240C5I5
Locus tag CKW09_RS14995 Protein ID WP_061794711.1
Coordinates 3160877..3161110 (-) Length 78 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW09_RS14965 3156048..3156422 + 375 WP_095098030.1 type II toxin-antitoxin system RelE/ParE family toxin -
CKW09_RS14970 3156415..3156717 + 303 WP_061794706.1 DNA-binding transcriptional regulator -
CKW09_RS14975 3156727..3157131 - 405 WP_061794707.1 flagellar protein FlhE -
CKW09_RS14980 3157131..3159209 - 2079 WP_095098033.1 flagellar biosynthesis protein FlhA -
CKW09_RS14985 3159202..3160353 - 1152 WP_095098036.1 flagellar type III secretion system protein FlhB -
CKW09_RS14990 3160479..3160877 - 399 WP_019452963.1 type II toxin-antitoxin system VapC family toxin Toxin
CKW09_RS14995 3160877..3161110 - 234 WP_061794711.1 antitoxin Antitoxin
CKW09_RS15000 3161237..3161881 - 645 WP_061794712.1 protein phosphatase CheZ -
CKW09_RS15005 3161892..3162281 - 390 WP_006326141.1 chemotaxis response regulator CheY -
CKW09_RS15010 3162385..3163434 - 1050 WP_061794713.1 chemotaxis response regulator protein-glutamate methylesterase -
CKW09_RS15015 3163434..3164306 - 873 WP_095098039.1 protein-glutamate O-methyltransferase CheR -
CKW09_RS15020 3164335..3165960 - 1626 WP_061794715.1 Tar ligand binding domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-125)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14876.02 Da        Isoelectric Point: 8.4955

>T293775 WP_019452963.1 NZ_LT906479:c3160877-3160479 [Serratia ficaria]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSVTYGELVHGVEKSSRPAVNARVVEDFVSRLDILDYGAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVDGLRLENWL

Download         Length: 399 bp


Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8915.93 Da        Isoelectric Point: 4.7954

>AT293775 WP_061794711.1 NZ_LT906479:c3161110-3160877 [Serratia ficaria]
MTLGSVFTNNRTQAVRLPTEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREEF

Download         Length: 234 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A240C5I5

References