Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 592291..592862 Replicon chromosome
Accession NZ_LT906479
Organism Serratia ficaria strain NCTC12148

Toxin (Protein)


Gene name relE Uniprot ID A0A6M5HME0
Locus tag CKW09_RS02765 Protein ID WP_061799809.1
Coordinates 592587..592862 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag CKW09_RS02760 Protein ID WP_013811307.1
Coordinates 592291..592578 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW09_RS02735 588059..589144 - 1086 WP_095095488.1 carbon-phosphorus lyase complex subunit PhnI -
CKW09_RS02740 589144..589725 - 582 WP_095095492.1 phosphonate C-P lyase system protein PhnH -
CKW09_RS02745 589728..590171 - 444 WP_095095495.1 phosphonate C-P lyase system protein PhnG -
CKW09_RS02750 590172..590900 - 729 WP_095095498.1 phosphonate metabolism transcriptional regulator PhnF -
CKW09_RS02755 591127..592185 + 1059 WP_095095501.1 permease -
CKW09_RS02760 592291..592578 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CKW09_RS02765 592587..592862 + 276 WP_061799809.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CKW09_RS02770 592868..593332 - 465 WP_095099987.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CKW09_RS02775 593528..595666 - 2139 WP_095095503.1 anaerobic ribonucleoside-triphosphate reductase -
CKW09_RS02780 595872..596786 - 915 WP_095095506.1 LysR family transcriptional regulator -
CKW09_RS02785 596891..597415 + 525 WP_095095508.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10766.50 Da        Isoelectric Point: 8.4940

>T293769 WP_061799809.1 NZ_LT906479:592587-592862 [Serratia ficaria]
MRIEWDNAALRDRERIFEFLYIFNPQAAEQADNEIDKAVKRLLDHPELGKPWYGKARKLLINKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT293769 WP_013811307.1 NZ_LT906479:592291-592578 [Serratia ficaria]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M5HME0

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References