Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 881862..882491 Replicon chromosome
Accession NZ_LT906478
Organism Listeria ivanovii subsp. ivanovii strain NCTC11846

Toxin (Protein)


Gene name pemK Uniprot ID A0A097BBV7
Locus tag CKV67_RS04250 Protein ID WP_025279828.1
Coordinates 882144..882491 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G2ZDP2
Locus tag CKV67_RS04245 Protein ID WP_014092317.1
Coordinates 881862..882140 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV67_RS04225 877202..878674 + 1473 WP_014092313.1 PH domain-containing protein -
CKV67_RS04230 878795..880174 + 1380 WP_014092314.1 protoporphyrinogen oxidase -
CKV67_RS04235 880176..880532 + 357 WP_014092315.1 holo-ACP synthase -
CKV67_RS04240 880550..881656 + 1107 WP_014092316.1 alanine racemase -
CKV67_RS04245 881862..882140 + 279 WP_014092317.1 CopG family ribbon-helix-helix protein Antitoxin
CKV67_RS04250 882144..882491 + 348 WP_025279828.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CKV67_RS04255 882741..883577 + 837 WP_014092318.1 STAS domain-containing protein -
CKV67_RS04260 883583..883939 + 357 WP_003721457.1 STAS domain-containing protein -
CKV67_RS04265 883942..884352 + 411 WP_014092320.1 anti-sigma regulatory factor -
CKV67_RS04270 884369..885373 + 1005 WP_025279829.1 PP2C family protein-serine/threonine phosphatase -
CKV67_RS04275 885525..885869 + 345 WP_014092322.1 anti sigma b factor antagonist RsbV -
CKV67_RS04280 885853..886326 + 474 WP_014092323.1 anti-sigma B factor RsbW -
CKV67_RS04285 886304..887083 + 780 WP_014092324.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12829.90 Da        Isoelectric Point: 6.4735

>T293767 WP_025279828.1 NZ_LT906478:882144-882491 [Listeria ivanovii subsp. ivanovii]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMVKVNQALEVSLGVVEF

Download         Length: 348 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10621.13 Da        Isoelectric Point: 4.2980

>AT293767 WP_014092317.1 NZ_LT906478:881862-882140 [Listeria ivanovii subsp. ivanovii]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVES
EAEDRNISILGG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097BBV7

Antitoxin

Source ID Structure
AlphaFold DB G2ZDP2

References