Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/CC2985(antitoxin)
Location 2323371..2323911 Replicon chromosome
Accession NZ_LT906476
Organism Legionella pneumophila strain NCTC11286

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag CKV96_RS10670 Protein ID WP_014844324.1
Coordinates 2323615..2323911 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID -
Locus tag CKV96_RS10665 Protein ID WP_027224835.1
Coordinates 2323371..2323625 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV96_RS10640 2318538..2319029 - 492 WP_016356972.1 hypothetical protein -
CKV96_RS10645 2319040..2319858 - 819 WP_014326980.1 Dam family site-specific DNA-(adenine-N6)-methyltransferase -
CKV96_RS10650 2320444..2321619 - 1176 WP_027224832.1 ISL3 family transposase -
CKV96_RS10655 2321774..2322352 + 579 WP_027224833.1 hypothetical protein -
CKV96_RS10660 2322457..2323023 + 567 WP_027224834.1 hypothetical protein -
CKV96_RS10665 2323371..2323625 + 255 WP_027224835.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CKV96_RS10670 2323615..2323911 + 297 WP_014844324.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKV96_RS10680 2324372..2325386 - 1015 Protein_2044 transposase -
CKV96_RS10685 2325649..2325858 + 210 WP_010947832.1 cold-shock protein -
CKV96_RS10690 2326098..2327504 + 1407 WP_014844326.1 ATP-dependent RNA helicase DbpA -
CKV96_RS10695 2327661..2328572 + 912 WP_014844327.1 cation diffusion facilitator family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2320444..2321619 1175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-81)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11582.28 Da        Isoelectric Point: 7.2728

>T293763 WP_014844324.1 NZ_LT906476:2323615-2323911 [Legionella pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Download         Length: 297 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9786.14 Da        Isoelectric Point: 9.9613

>AT293763 WP_027224835.1 NZ_LT906476:2323371-2323625 [Legionella pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKK
SHVK

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References