Detailed information of TA system TA029374

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2178915..2179798
• Replicon: chromosome
• Accession: NC_021149
• Organism: Azotobacter vinelandii CA

Toxin (Protein)

• Gene name: -
• Uniprot ID: M9YQ68
• Locus tag: AVCA_RS09955
• Protein ID: WP_012700772.1
• Coordinates: 2179361..2179798 (+)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: PrcA
• Uniprot ID: M9YEX5
• Locus tag: AVCA_RS09950
• Protein ID: WP_012700771.1
• Coordinates: 2178915..2179364 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVCA_RS09925	2174147..2174461	-	315	Protein_1985	TonB-dependent receptor	-
AVCA_RS09940	2175512..2177464	-	1953	WP_081434881.1	TonB-dependent receptor	-
AVCA_RS09945	2177672..2178715	+	1044	WP_175556059.1	LacI family DNA-binding transcriptional regulator	-
AVCA_RS09950	2178915..2179364	+	450	WP_012700771.1	DUF2384 domain-containing protein	Antitoxin
AVCA_RS09955	2179361..2179798	+	438	WP_012700772.1	RES family NAD+ phosphorylase	Toxin
AVCA_RS09960	2179819..2180220	-	402	WP_012699476.1	biopolymer transporter ExbD	-
AVCA_RS09965	2180222..2180932	-	711	WP_012700773.1	MotA/TolQ/ExbB proton channel family protein	-
AVCA_RS09970	2180966..2181826	-	861	WP_012700774.1	energy transducer TonB	-
AVCA_RS09975	2181959..2183068	-	1110	WP_012700775.1	LLM class flavin-dependent oxidoreductase	-
AVCA_RS09980	2183464..2183667	-	204	WP_012700776.1	hypothetical protein	-
AVCA_RS09985	2183798..2184661	-	864	WP_012700777.1	TauD/TfdA family dioxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2174475..2174810	335

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-140)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (97-143)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15778.14 Da
• Isoelectric Point: 4.7182

>T29374 WP_012700772.1 NC_021149:2179361-2179798 [Azotobacter vinelandii CA]
VILWRISAYADLGGVGGLRASGRWHHIGRPVVYAAESPAGAMLEVLVHLEIDPEDFPATLQLIRIELPDPVSLAELAPLP
ENWKSDPEATRAIGDRFLDTRSALLLPVPSAIIPCTTNYLFNPVHPEASGASIRVEQFPLDARLV

Nucleotide

• Length: 438 bp

>T29374 NC_021149:2179361-2179798 [Azotobacter vinelandii CA]
GTGATCCTCTGGCGGATCAGCGCCTACGCCGATCTCGGCGGAGTCGGCGGCTTGCGCGCCAGCGGCCGCTGGCATCATAT
CGGCAGGCCGGTCGTCTATGCGGCGGAAAGCCCGGCCGGGGCGATGCTGGAGGTGCTCGTCCATCTGGAAATCGATCCCG
AGGACTTCCCGGCGACGCTGCAGTTGATCCGCATCGAGCTTCCGGATCCGGTTTCGCTGGCCGAACTCGCGCCGCTGCCG
GAGAACTGGAAGTCCGACCCGGAAGCCACCCGCGCCATCGGCGACCGGTTTCTGGATACGAGGAGCGCCCTGCTGCTCCC
GGTACCCAGTGCCATCATCCCCTGCACGACCAACTATCTGTTCAACCCCGTACATCCCGAAGCCAGCGGCGCGAGCATCC
GGGTGGAGCAGTTTCCCCTCGACGCCCGGCTCGTCTGA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 17036.65 Da
• Isoelectric Point: 6.7346

>AT29374 WP_012700771.1 NC_021149:2178915-2179364 [Azotobacter vinelandii CA]
MLAEVLRDHGYTAYRVRLRSLLDIPESATDFEIHTRITQGFPAARLMQLTEAGVVTPLERDQIIPLRTLKSRIERDQPLT
VEESDRFFRAAHITAMAEAVFGDREKARRWLSKPKERFSGLTPMQMLTTQQGTAQVEEMLLQIVEGLAL

Nucleotide

• Length: 450 bp

>AT29374 NC_021149:2178915-2179364 [Azotobacter vinelandii CA]
ATGCTTGCCGAAGTGCTGCGTGACCACGGCTATACCGCGTACCGGGTGCGTCTTCGCAGTCTGCTGGACATTCCCGAGTC
GGCAACCGACTTCGAGATCCACACCCGGATTACCCAGGGCTTTCCCGCGGCACGCCTGATGCAGTTGACCGAGGCCGGGG
TTGTCACGCCACTGGAGCGCGACCAGATCATTCCCCTGCGCACCCTCAAGAGCCGCATCGAGCGCGATCAGCCGCTGACC
GTGGAGGAAAGCGACAGGTTCTTTCGCGCCGCTCACATCACGGCGATGGCCGAAGCCGTCTTCGGCGATCGCGAAAAGGC
CAGGCGCTGGCTTTCCAAACCCAAGGAGCGGTTTTCCGGCCTGACTCCCATGCAGATGCTCACCACCCAGCAGGGCACCG
CTCAGGTGGAAGAAATGTTGCTGCAGATCGTCGAAGGCCTGGCCTTGTGA

Structures

Toxin

• AlphaFold DB: M9YQ68

Antitoxin

• AlphaFold DB: M9YEX5