Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1643640..1645239 Replicon chromosome
Accession NZ_LT906471
Organism Bordetella pertussis strain NCTC13666

Toxin (Protein)


Gene name hipA Uniprot ID Q7VVM6
Locus tag CKW12_RS07965 Protein ID WP_003816876.1
Coordinates 1643899..1645239 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CKW12_RS07960 Protein ID WP_019247974.1
Coordinates 1643640..1643897 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW12_RS07940 1639303..1639914 - 612 WP_010931041.1 DUF2239 family protein -
CKW12_RS07945 1640137..1641597 + 1461 WP_003812368.1 IMP dehydrogenase -
CKW12_RS07950 1641694..1643286 + 1593 WP_010931040.1 glutamine-hydrolyzing GMP synthase -
CKW12_RS07960 1643640..1643897 + 258 WP_019247974.1 helix-turn-helix domain-containing protein Antitoxin
CKW12_RS07965 1643899..1645239 + 1341 WP_003816876.1 type II toxin-antitoxin system HipA family toxin Toxin
CKW12_RS07970 1645335..1646024 - 690 WP_010931038.1 TetR/AcrR family transcriptional regulator -
CKW12_RS07975 1646037..1647467 + 1431 WP_019247976.1 MFS transporter -
CKW12_RS07980 1647699..1648777 + 1079 Protein_1566 tellurite resistance/C4-dicarboxylate transporter family protein -
CKW12_RS07985 1649192..1650013 + 822 WP_014905903.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49632.79 Da        Isoelectric Point: 7.4158

>T293736 WP_003816876.1 NZ_LT906471:1643899-1645239 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Download         Length: 1341 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8815.04 Da        Isoelectric Point: 7.1642

>AT293736 WP_019247974.1 NZ_LT906471:1643640-1643897 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7VVM6

Antitoxin

Source ID Structure

References