Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 881865..882494 Replicon chromosome
Accession NZ_LT906466
Organism Listeria ivanovii subsp. ivanovii strain NCTC11007

Toxin (Protein)


Gene name pemK Uniprot ID A0A097BBV7
Locus tag CKV92_RS04250 Protein ID WP_025279828.1
Coordinates 882147..882494 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G2ZDP2
Locus tag CKV92_RS04245 Protein ID WP_014092317.1
Coordinates 881865..882143 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV92_RS04225 877205..878677 + 1473 WP_014092313.1 PH domain-containing protein -
CKV92_RS04230 878798..880177 + 1380 WP_014092314.1 protoporphyrinogen oxidase -
CKV92_RS04235 880179..880535 + 357 WP_014092315.1 holo-ACP synthase -
CKV92_RS04240 880553..881659 + 1107 WP_014092316.1 alanine racemase -
CKV92_RS04245 881865..882143 + 279 WP_014092317.1 CopG family ribbon-helix-helix protein Antitoxin
CKV92_RS04250 882147..882494 + 348 WP_025279828.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CKV92_RS04255 882744..883580 + 837 WP_014092318.1 STAS domain-containing protein -
CKV92_RS04260 883586..883942 + 357 WP_003721457.1 STAS domain-containing protein -
CKV92_RS04265 883945..884355 + 411 WP_014092320.1 anti-sigma regulatory factor -
CKV92_RS04270 884372..885376 + 1005 WP_025279829.1 PP2C family protein-serine/threonine phosphatase -
CKV92_RS04275 885528..885872 + 345 WP_014092322.1 anti sigma b factor antagonist RsbV -
CKV92_RS04280 885856..886329 + 474 WP_014092323.1 anti-sigma B factor RsbW -
CKV92_RS04285 886307..887086 + 780 WP_014092324.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12829.90 Da        Isoelectric Point: 6.4735

>T293733 WP_025279828.1 NZ_LT906466:882147-882494 [Listeria ivanovii subsp. ivanovii]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMVKVNQALEVSLGVVEF

Download         Length: 348 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10621.13 Da        Isoelectric Point: 4.2980

>AT293733 WP_014092317.1 NZ_LT906466:881865-882143 [Listeria ivanovii subsp. ivanovii]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVES
EAEDRNISILGG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097BBV7

Antitoxin

Source ID Structure
AlphaFold DB G2ZDP2

References