Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1585165..1585689 Replicon chromosome
Accession NZ_LT906464
Organism Staphylococcus muscae strain NCTC13833

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CKV93_RS07800 Protein ID WP_095117482.1
Coordinates 1585165..1585518 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CKV93_RS07805 Protein ID WP_095117483.1
Coordinates 1585519..1585689 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV93_RS07780 1582234..1583007 - 774 WP_095117478.1 RNA polymerase sigma factor SigB -
CKV93_RS07785 1582979..1583461 - 483 WP_095117479.1 anti-sigma B factor RsbW -
CKV93_RS07790 1583463..1583789 - 327 WP_095117480.1 anti-sigma factor antagonist -
CKV93_RS07795 1583865..1584893 - 1029 WP_095117481.1 PP2C family protein-serine/threonine phosphatase -
CKV93_RS07800 1585165..1585518 - 354 WP_095117482.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CKV93_RS07805 1585519..1585689 - 171 WP_095117483.1 antitoxin MazE Antitoxin
CKV93_RS07810 1585778..1586926 - 1149 WP_095117484.1 alanine racemase -
CKV93_RS07815 1586954..1587313 - 360 WP_095117485.1 holo-ACP synthase -
CKV93_RS07820 1587310..1587885 - 576 WP_095117486.1 PH domain-containing protein -
CKV93_RS07825 1587875..1589380 - 1506 WP_095117487.1 PH domain-containing protein -
CKV93_RS07830 1589373..1589846 - 474 WP_095117488.1 PH domain-containing protein -
CKV93_RS07835 1589981..1590682 - 702 WP_095117489.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13030.17 Da        Isoelectric Point: 10.2682

>T293731 WP_095117482.1 NZ_LT906464:c1585518-1585165 [Staphylococcus muscae]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
VDKNRLKEKLTFLSDEKMKEVNNALGISLGLQVVQSR

Download         Length: 354 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.02 Da        Isoelectric Point: 4.2313

>AT293731 WP_095117483.1 NZ_LT906464:c1585689-1585519 [Staphylococcus muscae]
MSVFNQVKFKNLEQSLKEGYAQMADLNLSLATEAYSVECEACDCNESHLLSKHQDD

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References