Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2962840..2963491 Replicon chromosome
Accession NZ_LT906461
Organism Bordetella hinzii strain NCTC13200

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CKW36_RS13645 Protein ID WP_080666588.1
Coordinates 2962840..2963016 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H4WIS4
Locus tag CKW36_RS13650 Protein ID WP_029580464.1
Coordinates 2963075..2963491 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW36_RS13625 2958020..2959675 + 1656 WP_029580468.1 PAS domain-containing methyl-accepting chemotaxis protein -
CKW36_RS13630 2959814..2960302 + 489 WP_029580467.1 membrane protein -
CKW36_RS13635 2960489..2961445 - 957 WP_144417577.1 hypothetical protein -
CKW36_RS13640 2961759..2962451 + 693 WP_029580465.1 SOS response-associated peptidase family protein -
CKW36_RS13645 2962840..2963016 + 177 WP_080666588.1 type II toxin-antitoxin system HicA family toxin Toxin
CKW36_RS13650 2963075..2963491 + 417 WP_029580464.1 antitoxin Antitoxin
CKW36_RS23280 2963491..2963988 + 498 WP_144417576.1 hypothetical protein -
CKW36_RS13655 2963964..2964470 - 507 WP_080666598.1 DUF2514 family protein -
CKW36_RS13660 2964497..2964988 - 492 WP_029580462.1 hypothetical protein -
CKW36_RS13665 2964994..2965434 - 441 WP_029580461.1 hypothetical protein -
CKW36_RS13670 2965534..2966133 - 600 WP_029580460.1 hypothetical protein -
CKW36_RS13675 2966161..2968146 - 1986 WP_029580459.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2961759..3009465 47706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6522.48 Da        Isoelectric Point: 11.0738

>T293725 WP_080666588.1 NZ_LT906461:2962840-2963016 [Bordetella hinzii]
VKTSEFRRWLAEQGATFKEGSAHTKVYLNGKQTTLPRHGSQEIGEGLRRAILKQLGIK

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15149.53 Da        Isoelectric Point: 4.6381

>AT293725 WP_029580464.1 NZ_LT906461:2963075-2963491 [Bordetella hinzii]
MLRYPAKIAPDTVGFMVTFRDIPEALSAGQTREEAEAMAADALLVAMDFYFEDRRPVPPPSAPVGDEVMIALPASASAKV
LLLNEMLAQQVTPSELARRMETRKQEVNRIIDLNHATKIDTIAAALTSLGRELELTVR

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H4WIS4

References