Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 1640621..1641399 Replicon chromosome
Accession NZ_LT906461
Organism Bordetella hinzii strain NCTC13200

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H4W6J9
Locus tag CKW36_RS07505 Protein ID WP_029577226.1
Coordinates 1640621..1641124 (-) Length 168 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H4W2N5
Locus tag CKW36_RS07510 Protein ID WP_029577227.1
Coordinates 1641121..1641399 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW36_RS07465 1635720..1636190 - 471 WP_029577219.1 hypothetical protein -
CKW36_RS07470 1636187..1636399 - 213 WP_029577220.1 helix-turn-helix domain-containing protein -
CKW36_RS07475 1636588..1636812 - 225 WP_029577221.1 DUF2188 domain-containing protein -
CKW36_RS07480 1636878..1637834 - 957 WP_029577222.1 hypothetical protein -
CKW36_RS07485 1637843..1638649 - 807 WP_029577223.1 hypothetical protein -
CKW36_RS07490 1638658..1638825 + 168 Protein_1478 DUF2924 domain-containing protein -
CKW36_RS07495 1638822..1640177 + 1356 WP_029577224.1 recombinase family protein -
CKW36_RS07500 1640174..1640605 + 432 WP_029577225.1 hypothetical protein -
CKW36_RS07505 1640621..1641124 - 504 WP_029577226.1 GNAT family N-acetyltransferase Toxin
CKW36_RS07510 1641121..1641399 - 279 WP_029577227.1 DUF1778 domain-containing protein Antitoxin
CKW36_RS07515 1641848..1642126 - 279 WP_029577228.1 head-tail connector protein -
CKW36_RS07520 1642123..1642458 - 336 WP_029577229.1 phage head closure protein -
CKW36_RS07525 1642597..1644093 - 1497 WP_029577230.1 terminase -
CKW36_RS07530 1644090..1644548 - 459 WP_029577231.1 hypothetical protein -
CKW36_RS07535 1644599..1645036 - 438 WP_029577232.1 HNH endonuclease -
CKW36_RS07540 1645033..1646247 - 1215 WP_029577233.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1611341..1672778 61437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-147)

Antitoxin

Vibrio phage ICP1, Orf50

(11-86)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18326.13 Da        Isoelectric Point: 7.2395

>T293724 WP_029577226.1 NZ_LT906461:c1641124-1640621 [Bordetella hinzii]
MSNDYSPVRKLAATDQVDAFDCGQAALNQFLQRYALINQKANSAQTYVCCQGDVVVGFYSLAVGSVDPEAAPSRVMKGLA
RHPVPVMILARLAVDKAHQCKGLGQALLKDALLRTAQAADIAGIRCLLVHAKDDAARQWYESWEFEPSPTDPYHLFLMLK
DLKSMLS

Download         Length: 504 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10344.85 Da        Isoelectric Point: 9.2519

>AT293724 WP_029577227.1 NZ_LT906461:c1641399-1641121 [Bordetella hinzii]
MSTLNLSKTERIDVRASTPVKQLLQEAARACHKNVSEFLLDAGVTAAAQTLADRRQFVLDDTQWQAFQEALDRPVQSKPR
LKKLLREPGVLD

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H4W6J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0H4W2N5

References