Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-doc
Location 2420408..2421009 Replicon chromosome
Accession NZ_LT906460
Organism Staphylococcus simiae strain NCTC13838

Toxin (Protein)


Gene name pemK Uniprot ID G5JI18
Locus tag CKV88_RS11380 Protein ID WP_002463367.1
Coordinates 2420408..2420743 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G5JI19
Locus tag CKV88_RS11385 Protein ID WP_002463369.1
Coordinates 2420740..2421009 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV88_RS11355 2416406..2416840 - 435 WP_002463357.1 MarR family transcriptional regulator -
CKV88_RS11360 2417033..2417956 - 924 WP_002463358.1 zinc ABC transporter substrate-binding protein -
CKV88_RS11365 2418150..2418431 + 282 WP_002463360.1 N-acetyltransferase -
CKV88_RS11370 2418693..2419499 + 807 WP_002463362.1 VOC family protein -
CKV88_RS11375 2419569..2420231 - 663 WP_002463364.1 NAD(P)H-dependent oxidoreductase -
CKV88_RS11380 2420408..2420743 - 336 WP_002463367.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CKV88_RS11385 2420740..2421009 - 270 WP_002463369.1 hypothetical protein Antitoxin
CKV88_RS11390 2421728..2422720 + 993 WP_002463371.1 D-lactate dehydrogenase -
CKV88_RS11395 2422927..2423217 - 291 WP_002463373.1 hypothetical protein -
CKV88_RS11400 2423233..2424150 - 918 WP_002463375.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2425159..2426238 1079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12835.91 Da        Isoelectric Point: 8.9154

>T293721 WP_002463367.1 NZ_LT906460:c2420743-2420408 [Staphylococcus simiae]
MSVKQFDILYIDLDPTKGREKQKIRPCLVVNNDMTIKGTNFVWILPITSREPKFPTDIEVKSKNRLITGVIDTVQIRALD
LNAREYSYRDELQDSLKNDVLLAINAFLKPQ

Download         Length: 336 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10146.39 Da        Isoelectric Point: 4.8952

>AT293721 WP_002463369.1 NZ_LT906460:c2421009-2420740 [Staphylococcus simiae]
MVETLNDVNKTNERVFKSGNSKAISLSKQTLQLTHFEIGDKVEVQQMNDGIFIKKKEETIEDKITNFFKNGGKYTESEID
FGESVGREI

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G5JI18

Antitoxin

Source ID Structure
AlphaFold DB G5JI19

References